Effect of phosphodiesterase 7 (PDE7) inhibitors in experimental autoimmune encephalomyelitis mice. Discovery of a new chemically diverse family of compounds.

@article{Redondo2012EffectOP,
  title={Effect of phosphodiesterase 7 (PDE7) inhibitors in experimental autoimmune encephalomyelitis mice. Discovery of a new chemically diverse family of compounds.},
  author={M. P. Mart{\'i}n Redondo and Jos{\'e} Brea and Daniel I Perez and Ignacio Soteras and Cristina Val and Concepci{\'o}n P{\'e}rez and Jose A Morales-Garc{\'i}a and Sandra Alonso-Gil and Nuria Pa{\'u}l-Fern{\'a}ndez and Roc{\'i}o Mart{\'i}n-{\'A}lvarez and Mar{\'i}a Isabel Cadavid and Mar{\'i}a I. Loza and Ana Perez-Castillo and Guadalupe Mengod and Nuria E. Campillo and Ana Mercedes Victoria Mart{\'i}nez and Carmen Gil},
  journal={Journal of medicinal chemistry},
  year={2012},
  volume={55 7},
  pages={
          3274-84
        }
}
Phosphodiesterase (PDE) 7 is involved in proinflammatory processes, being widely expressed both on lymphocytes and on certain brain regions. Specific inhibitors of PDE7 have been recently reported as potential new drugs for the treatment of neurological disorders because of their ability to increase intracellular levels of cAMP and thus to modulate the inflammatory process, as a neuroprotective well-established strategy. Multiple sclerosis is an unmet disease in which pathologies on the immune… CONTINUE READING
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