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Cryopyrin-Associated Periodic Syndromes

Known as: Cryopyrin-Associated Periodic Syndrome, Cryopyrin Associated Periodic Syndromes, CAPS 
A group of rare autosomal dominant diseases, commonly characterized by atypical URTICARIA (hives) with systemic symptoms that develop into end-organ… Expand
National Institutes of Health

Related topics

Related topics

12 relations
Autoimmune DiseasesHereditary DiseasesIn BloodMicrobiological
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Narrower (4)

Chronic Infantile Neurological, Cutaneous, and Articular SyndromeFamilial Cold Autoinflammatory Syndrome 2Familial cold urticariaMuckle-Wells Syndrome

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation
The NLRP3 inflammasome is a critical component of the innate immune system that mediates caspase-1 activation and the secretion… Expand
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Highly Cited
2015
Highly Cited
2015
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
The NOD-like receptor (NLR) family, pyrin domain–containing protein 3 (NLRP3) inflammasome is a component of the inflammatory… Expand
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Review
2010
Review
2010
IL-1 pathways in inflammation and human diseases
Interleukin (IL)-1 was first cloned in the 1980s, and rapidly emerged as a key player in the regulation of inflammatory processes… Expand
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Highly Cited
2009
Highly Cited
2009
Use of canakinumab in the cryopyrin-associated periodic syndrome.
BACKGROUND The cryopyrin-associated periodic syndrome (CAPS) is a rare inherited inflammatory disease associated with… Expand
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Highly Cited
2009
Highly Cited
2009
In vivo regulation of interleukin 1β in patients with cryopyrin-associated periodic syndromes
The investigation of interleukin 1β (IL-1β) in human inflammatory diseases is hampered by the fact that it is virtually… Expand
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Review
2008
Review
2008
Cryopyrin‐associated periodic syndromes and autoinflammation
Autoinflammatory syndromes are a distinct class of inherited diseases of cytokine dysregulation with important cutaneous features… Expand
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Highly Cited
2006
Highly Cited
2006
Gout-associated uric acid crystals activate the NALP3 inflammasome
Development of the acute and chronic inflammatory responses known as gout and pseudogout are associated with the deposition of… Expand
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Highly Cited
2006
Highly Cited
2006
Cryopyrin activates the inflammasome in response to toxins and ATP
A crucial part of the innate immune response is the assembly of the inflammasome, a cytosolic complex of proteins that activates… Expand
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Highly Cited
2006
Highly Cited
2006
Critical Role for Cryopyrin/Nalp3 in Activation of Caspase-1 in Response to Viral Infection and Double-stranded RNA*>
Viral infection induces the production of interleukin (IL)-1β and IL-18 in macrophages through the activation of caspase-1, but… Expand
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Review
2005
Review
2005
NOD-LRR proteins: role in host-microbial interactions and inflammatory disease.
Nods are cytosolic proteins that contain a nucleotide-binding oligomerization domain (NOD). These proteins include key regulators… Expand
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