Conserved sequence

Known as: Evolutionarily conserved, Highly conserved, Gene conservation 
In biology, conserved sequences are similar or identical sequences that occur within nucleic acid sequences (such as RNA and DNA sequences), protein… (More)
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Related topics

Related topics

13 relations
BLOSUMClustalW/ClustalXDeep homologyHomology (biology)
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Broader (2)

BioinformaticsComputational phylogenetics

Papers overview

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Highly Cited
2010
Highly Cited
2010
ConSurf 2010: calculating evolutionary conservation in sequence and structure of proteins and nucleic acids
It is informative to detect highly conserved positions in proteins and nucleic acid sequence/structure since they are often… (More)
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Highly Cited
2009
Highly Cited
2009
The human colon cancer methylome shows similar hypo-and hypermethylation at conserved tissue-specific CpG island shores
For the past 25 years, it has been known that alterations in DNA methylation (DNAm) occur in cancer, including hypomethylation of… (More)
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Highly Cited
2005
Highly Cited
2005
Identification and analysis of alternative splicing events conserved in human and mouse Gene
Alternative pre-mRNA splicing affects a majority of human genes and plays important roles in development and disease. Alternative… (More)
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Highly Cited
2004
Highly Cited
2004
Computational identification of evolutionarily conserved exons
Phylogenetic hidden Markov models (phylo-HMMs) have recently been proposed as a means for addressing a multi-species version of… (More)
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Highly Cited
2003
Highly Cited
2003
Structure and conserved RNA binding of the PAZ domain
The discovery of RNA-mediated gene-silencing pathways, including RNA interference, highlights a fundamental role of short RNAs in… (More)
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Highly Cited
2002
Highly Cited
2002
CDD: a database of conserved domain alignments with links to domain three-dimensional structure
The Conserved Domain Database (CDD) is a compilation of multiple sequence alignments representing protein domains conserved in… (More)
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Highly Cited
2001
Highly Cited
2001
Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12.
Escherichia coli O157:H7 is a major food-borne infectious pathogen that causes diarrhea, hemorrhagic colitis, and hemolytic… (More)
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Highly Cited
1997
Highly Cited
1997
Subunit interactions in ABC transporters: a conserved sequence in hydrophobic membrane proteins of periplasmic permeases defines an important site of interaction with the ATPase subunits.
The cytoplasmic membrane proteins of bacterial binding protein-dependent transporters belong to the superfamily of ABC… (More)
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Highly Cited
1992
Highly Cited
1992
Conserved sequence motifs in the initiator proteins for rolling circle DNA replication encoded by diverse replicons from eubacteria, eucaryotes and archaebacteria
An amino acid motif was identified that consists of the sequence HisHydrHisHydrHydrHydr (Hydr--bulky hydrophobic residue) and is… (More)
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Highly Cited
1974
Highly Cited
1974
The 3'-terminal sequence of Escherichia coli 16S ribosomal RNA: complementarity to nonsense triplets and ribosome binding sites.
With a stepwise degradation and terminal labeling procedure the 3'-terminal sequence of E. coli 16S ribosomal RNA is shown to be… (More)
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