Conserved sequence

Known as: Evolutionarily conserved, Highly conserved, Gene conservation 
In biology, conserved sequences are similar or identical sequences that occur within nucleic acid sequences (such as RNA and DNA sequences), protein… (More)
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Highly Cited
2010
Highly Cited
2010
It is informative to detect highly conserved positions in proteins and nucleic acid sequence/structure since they are often… (More)
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Highly Cited
2009
Highly Cited
2009
For the past 25 years, it has been known that alterations in DNA methylation (DNAm) occur in cancer, including hypomethylation of… (More)
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Highly Cited
2005
Highly Cited
2005
Alternative pre-mRNA splicing affects a majority of human genes and plays important roles in development and disease. Alternative… (More)
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Highly Cited
2004
Highly Cited
2004
Phylogenetic hidden Markov models (phylo-HMMs) have recently been proposed as a means for addressing a multi-species version of… (More)
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Highly Cited
2003
Highly Cited
2003
The discovery of RNA-mediated gene-silencing pathways, including RNA interference, highlights a fundamental role of short RNAs in… (More)
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Highly Cited
2002
Highly Cited
2002
The Conserved Domain Database (CDD) is a compilation of multiple sequence alignments representing protein domains conserved in… (More)
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Highly Cited
2001
Highly Cited
2001
Escherichia coli O157:H7 is a major food-borne infectious pathogen that causes diarrhea, hemorrhagic colitis, and hemolytic… (More)
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Highly Cited
1997
Highly Cited
1997
The cytoplasmic membrane proteins of bacterial binding protein-dependent transporters belong to the superfamily of ABC… (More)
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Highly Cited
1992
Highly Cited
1992
An amino acid motif was identified that consists of the sequence HisHydrHisHydrHydrHydr (Hydr--bulky hydrophobic residue) and is… (More)
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Highly Cited
1974
Highly Cited
1974
With a stepwise degradation and terminal labeling procedure the 3'-terminal sequence of E. coli 16S ribosomal RNA is shown to be… (More)
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