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Compound Q

Known as: alpha-Trichosanthin, Trichosanthin [Chemical/Ingredient], Proteins, specific or class, trichosanthins 
Plant-derived ribosome-inactivating protein (RIP) purified from the Chinese medicinal herb tian-hua-fen which is obtained from the root tubers of… 
National Institutes of Health

Related topics

Related topics

12 relations

Broader (3)

Abortifacient Agents, NonsteroidalAnti-HIV AgentsAntineoplastic Agents, Phytogenic

Narrower (1)

GLQ-223
In BloodProcess of secretionTrichosanthisagonists

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Trichosanthin inhibits DNA methyltransferase and restores methylation-silenced gene expression in human cervical cancer cells.
Epigenetic silencing of tumor suppressor genes is a well-established oncogenic process and the reactivation of tumor suppressor… 
Highly Cited
2007
Highly Cited
2007
Trichosanthin induced apoptosis in HL-60 cells via mitochondrial and endoplasmic reticulum stress signaling pathways.
2003
2003
Independency of anti-HIV-1 activity from ribosome-inactivating activity of trichosanthin.
2000
2000
The membrane insertion of trichosanthin is membrane-surface-pH dependent.
Trichosanthin (TCS) is the active component extracted from Tianhuafen, a traditional herbal medicine that has been used for… 
Highly Cited
1999
Highly Cited
1999
Anti-HIV Agent Trichosanthin Enhances the Capabilities of Chemokines to Stimulate Chemotaxis and G Protein Activation, and This Is Mediated through Interaction of Trichosanthin and Chemokine…
Trichosanthin (TCS), an active protein component isolated from a traditional Chinese medicinal herb Trichosanthes kirilowii, has… 
Review
1994
Review
1994
Minireview: trichosanthin--a protein with multiple pharmacological properties.
1991
1991
Cloning of trichosanthin cDNA and its expression in Escherichia coli.
Highly Cited
1990
Highly Cited
1990
The safety and pharmacokinetics of GLQ223 in subjects with AIDS and AIDS-related complex: a phase I study.
A phase I dose-escalation study was performed to evaluate the safety and pharmacokinetics of a single intravenous infusion of… 
1988
1988
Trichokirin, a ribosome-inactivating protein from the seeds of Trichosanthes kirilowii Maximowicz. Purification, partial characterization and use for preparation of immunotoxins.
A protein, here named trichokirin, was extracted from the seeds of Trichosanthes kirilowii and purified by ion-exchange and gel… 
Highly Cited
1986
Highly Cited
1986
Homology of trichosanthin and ricin A chain
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