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Complement Factor I

Known as: Inactivator, Complement C4b-C3b, C4b-C3b Inactivator, Complement, Complement 3b Complement 4b Inactivator 
A plasma serine proteinase that cleaves the alpha-chains of C3b and C4b in the presence of the cofactors COMPLEMENT FACTOR H and C4-binding protein… Expand
National Institutes of Health

Papers overview

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Highly Cited
1980
Highly Cited
1980
  • K. Whaley
  • The Journal of experimental medicine
  • 1980
  • Corpus ID: 445285
Short-term cultures of human peripheral blood monocytes were shown to synthesize the alternative pathway complement components C3… Expand
  • figure 1
  • figure 5
  • table I
Highly Cited
1979
Highly Cited
1979
We recently described the isolation from human serum of a serum protein (C4 binding protein) that functions as an essential… Expand
Highly Cited
1978
Highly Cited
1978
The alternative or properdin pathway of complement is primarily controlled by the endopeptidase C3b inactivator (C3bINA) and the… Expand
Highly Cited
1978
Highly Cited
1978
We recently described the isolation from human serum of a high molecular weight protein with specific binding affinity for fluid… Expand
  • figure 4
Highly Cited
1977
Highly Cited
1977
The complement regulatory enzyme, C3b inactivator (C3bINA), has been purified from human serum by affinity chromatography on an… Expand
  • table I
  • figure 3
  • figure 4
  • figure 5
  • table II
Highly Cited
1977
Highly Cited
1977
  • D. Fearon, K. Austen
  • Proceedings of the National Academy of Sciences…
  • 1977
  • Corpus ID: 38312059
The surface of zymosan (Zy), by affording a protected microenvironment for C3b and the amplification convertase stabilized by… Expand
Highly Cited
1976
Highly Cited
1976
An inhibitory activity for an erythrocyte in termediate bearing the properdin (P)-stabilized amplification C3 convertase, PC3bBb… Expand
Highly Cited
1976
Highly Cited
1976
C3b inactivator accelerator (A-C3bINA) was isolated from human plasma. An antiserum produced against the purified protein gave a… Expand
  • figure 3
  • figure 5
  • table I
  • figure 8
  • figure 9
Highly Cited
1971
Highly Cited
1971
C3b inactivator (C3bINA), a normal serum protein that destroys the ability of cells bearing C3b to participate in immune… Expand
Highly Cited
1970
Highly Cited
1970
The failure of human serum to give rise to anaphylatoxin activity could be attributed to the presence of a potent inactivator of… Expand
  • table I
  • figure 1
  • figure 2
  • figure 5
  • table I