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Complement Factor I

Known as: Inactivator, Complement C4b-C3b, C4b-C3b Inactivator, Complement, Complement 3b Complement 4b Inactivator 
A plasma serine proteinase that cleaves the alpha-chains of C3b and C4b in the presence of the cofactors COMPLEMENT FACTOR H and C4-binding protein… Expand
National Institutes of Health

Papers overview

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Highly Cited
1980
Highly Cited
1980
  • K. Whaley
  • The Journal of experimental medicine
  • 1980
  • Corpus ID: 445285
Short-term cultures of human peripheral blood monocytes were shown to synthesize the alternative pathway complement components C3… Expand
  • figure 1
  • figure 5
  • table I
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Highly Cited
1979
Highly Cited
1979
We recently described the isolation from human serum of a serum protein (C4 binding protein) that functions as an essential… Expand
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Highly Cited
1978
Highly Cited
1978
We recently described the isolation from human serum of a high molecular weight protein with specific binding affinity for fluid… Expand
  • figure 4
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Highly Cited
1978
Highly Cited
1978
The alternative or properdin pathway of complement is primarily controlled by the endopeptidase C3b inactivator (C3bINA) and the… Expand
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Highly Cited
1977
Highly Cited
1977
The complement regulatory enzyme, C3b inactivator (C3bINA), has been purified from human serum by affinity chromatography on an… Expand
  • table I
  • figure 3
  • figure 4
  • figure 5
  • table II
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Highly Cited
1977
Highly Cited
1977
  • D. Fearon, K. Austen
  • Proceedings of the National Academy of Sciences…
  • 1977
  • Corpus ID: 38312059
The surface of zymosan (Zy), by affording a protected microenvironment for C3b and the amplification convertase stabilized by… Expand
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Highly Cited
1976
Highly Cited
1976
An inhibitory activity for an erythrocyte in termediate bearing the properdin (P)-stabilized amplification C3 convertase, PC3bBb… Expand
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Highly Cited
1976
Highly Cited
1976
C3b inactivator accelerator (A-C3bINA) was isolated from human plasma. An antiserum produced against the purified protein gave a… Expand
  • figure 3
  • figure 5
  • table I
  • figure 8
  • figure 9
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Highly Cited
1971
Highly Cited
1971
C3b inactivator (C3bINA), a normal serum protein that destroys the ability of cells bearing C3b to participate in immune… Expand
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Highly Cited
1970
Highly Cited
1970
The failure of human serum to give rise to anaphylatoxin activity could be attributed to the presence of a potent inactivator of… Expand
  • table I
  • figure 1
  • figure 2
  • figure 5
  • table I
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