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Complement Factor I

Known as: Inactivator, Complement C4b-C3b, C4b-C3b Inactivator, Complement, Complement 3b Complement 4b Inactivator 
A plasma serine proteinase that cleaves the alpha-chains of C3b and C4b in the presence of the cofactors COMPLEMENT FACTOR H and C4-binding protein… 
National Institutes of Health

Related topics

Related topics

12 relations
CFI geneComplement C3 ConvertasesFibrinogenProcess of secretion

Broader (2)

Complement 3b InactivatorsComplement Inactivating Agents

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1993
1993
Immune lysis of Trypanosoma congolense: generation of a soluble covalent complex of variant surface glycoprotein and bovine complement component C3b.
Highly Cited
1985
Highly Cited
1985
Binding of complement component C3b to glycoprotein C is modulated by sialic acid on herpes simplex virus type 1-infected cells
Neuraminidase treatment of cells infected with herpes simplex virus type 1 (HSV-1) markedly enhanced the binding of complement… 
Highly Cited
1985
Highly Cited
1985
Sequential studies of complement activation in systemic lupus erythematosus.
C1 and C3 activation, measured as C1r-C1s-C1 inactivator C1s-C1r-C1IA complexes in serum and circulating C3d were studied in… 
1982
1982
C3b inactivator deficiency with immune complex manifestations.
We report a complete C3b inactivator deficiency in a 28-year-old patient referred for bronchiectasis and recurrent pneumonia. In… 
1981
1981
The separation of functionally distinct forms of the third component of human complement (C3).
Complement component C3 prepared by the method of Tack & Prahl [(1976) Biochemistry 15, 4513-4521] was found to contain the… 
1980
1980
Control of serum C3 levels by beta 1H and C3b inactivator.
In serum specimens from 50 normal adults, a high correlation was found between the sum of the levels of the control proteins of… 
1977
1977
Correlations between serum factor B and C3b inactivator levels in normal subjects and in patients with infections, nephrosis and hypocomplementaemic glomerulonephritis.
In normal subjects, factor B and C3b inactivator (KAF) levels were linearly related (r = 0-71); factor B levels in subjects with… 
1976
1976
Studies of the presence of membrane receptors for complement, IgG and the sheep erythrocyte rosetting capacity on the same human lymphocytes
Normal peripheral blood lymphocytes were tested by a mixed rosette method, employing different sized erythrocytes as indicators… 
Highly Cited
1975
Highly Cited
1975
Isolation and analysis of the mechanism of action of an inactivator of C4b in normal human serum
A complement regulatory principle, C4b inactivator, was isolated in a partially purified form from normal human serum. The C4b… 
Highly Cited
1974
Highly Cited
1974
RECEPTOR FOR SOLUBLE C3 AND C3b ON HUMAN LYMPHOBLASTOID (RAJI) CELLS
This study describes the presence of a receptor for fluid phase human C3 and C3b on Raji cell membranes. The binding of C3 and… 
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