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Complement Factor I

Known as: Inactivator, Complement C4b-C3b, C4b-C3b Inactivator, Complement, Complement 3b Complement 4b Inactivator 
A plasma serine proteinase that cleaves the alpha-chains of C3b and C4b in the presence of the cofactors COMPLEMENT FACTOR H and C4-binding protein… Expand
National Institutes of Health

Related topics

Related topics

12 relations
CFI geneComplement C3 ConvertasesFibrinogenProcess of secretion
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Broader (2)

Complement 3b InactivatorsComplement Inactivating Agents

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1980
Highly Cited
1980
Biosynthesis of the complement components and the regulatory proteins of the alternative complement pathway by human peripheral blood monocytes
  • K. Whaley
  • The Journal of experimental medicine
  • 1980
    • Corpus ID: 445285
Short-term cultures of human peripheral blood monocytes were shown to synthesize the alternative pathway complement components C3… Expand
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  • table I
Highly Cited
1979
Highly Cited
1979
Modulation of the classical pathway C3 convertase by plasma proteins C4 binding protein and C3b inactivator.
We recently described the isolation from human serum of a serum protein (C4 binding protein) that functions as an essential… Expand
Highly Cited
1978
Highly Cited
1978
Complement C3 convertase: cell surface restriction of beta1H control and generation of restriction on neuraminidase-treated cells.
The alternative or properdin pathway of complement is primarily controlled by the endopeptidase C3b inactivator (C3bINA) and the… Expand
Highly Cited
1978
Highly Cited
1978
Human C4-binding protein. II. Role in proteolysis of C4b by C3b- inactivator
We recently described the isolation from human serum of a high molecular weight protein with specific binding affinity for fluid… Expand
  • figure 4
Highly Cited
1977
Highly Cited
1977
Human complement C3b inactivator: isolation, characterization, and demonstration of an absolute requirement for the serum protein beta1H for cleavage of C3b and C4b in solution
The complement regulatory enzyme, C3b inactivator (C3bINA), has been purified from human serum by affinity chromatography on an… Expand
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  • figure 3
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  • table II
Highly Cited
1977
Highly Cited
1977
Activation of the alternative complement pathway due to resistance of zymosan-bound amplification convertase to endogenous regulatory mechanisms.
  • D. Fearon, K. Austen
  • Proceedings of the National Academy of Sciences…
  • 1977
    • Corpus ID: 38312059
The surface of zymosan (Zy), by affording a protected microenvironment for C3b and the amplification convertase stabilized by… Expand
Highly Cited
1976
Highly Cited
1976
Control of the amplification convertase of complement by the plasma protein beta1H.
An inhibitory activity for an erythrocyte in termediate bearing the properdin (P)-stabilized amplification C3 convertase, PC3bBb… Expand
Highly Cited
1976
Highly Cited
1976
Modulation of the alternative complement pathways by beta 1 H globulin
C3b inactivator accelerator (A-C3bINA) was isolated from human plasma. An antiserum produced against the purified protein gave a… Expand
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  • table I
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  • figure 9
Highly Cited
1971
Highly Cited
1971
C3b inactivator of man. II. Fragments produced by C3b inactivator cleavage of cell-bound or fluid phase C3b.
C3b inactivator (C3bINA), a normal serum protein that destroys the ability of cells bearing C3b to participate in immune… Expand
Highly Cited
1970
Highly Cited
1970
Anaphylatoxin inactivator of human plasma: its isolation and characterization as a carboxypeptidase.
The failure of human serum to give rise to anaphylatoxin activity could be attributed to the presence of a potent inactivator of… Expand
  • table I
  • figure 1
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  • figure 5
  • table I
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