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Complement Factor I

Known as: Inactivator, Complement C4b-C3b, C4b-C3b Inactivator, Complement, Complement 3b Complement 4b Inactivator 
A plasma serine proteinase that cleaves the alpha-chains of C3b and C4b in the presence of the cofactors COMPLEMENT FACTOR H and C4-binding protein… 
National Institutes of Health

Related topics

Related topics

12 relations
CFI geneComplement C3 ConvertasesFibrinogenProcess of secretion

Broader (2)

Complement 3b InactivatorsComplement Inactivating Agents

Papers overview

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2004
2004
Genetic polymorphism of human factor I (C3b inactivator)
SummaryGenetic polymorphism of human factor I (C3b inactivator) has been described using polyacrylamide gel isoelectric focusing… 
1986
1986
Deficiencies in regulator proteins. 4. Anaphylatoxin inactivator.
Highly Cited
1985
Highly Cited
1985
Sequential studies of complement activation in systemic lupus erythematosus.
C1 and C3 activation, measured as C1r-C1s-C1 inactivator C1s-C1r-C1IA complexes in serum and circulating C3d were studied in… 
1982
1982
C3b inactivator deficiency with immune complex manifestations.
We report a complete C3b inactivator deficiency in a 28-year-old patient referred for bronchiectasis and recurrent pneumonia. In… 
1982
1982
Elevation of serum chemotactic factor inactivator activity during acute inflammatory reactions in patients with hypersensitivity pneumonitis.
Inflammatory mediators such as the vasoactive and chemotactic factors derived from the activation of the complement system are… 
1981
1981
The separation of functionally distinct forms of the third component of human complement (C3).
Complement component C3 prepared by the method of Tack & Prahl [(1976) Biochemistry 15, 4513-4521] was found to contain the… 
1980
1980
Control of serum C3 levels by beta 1H and C3b inactivator.
In serum specimens from 50 normal adults, a high correlation was found between the sum of the levels of the control proteins of… 
1977
1977
Correlations between serum factor B and C3b inactivator levels in normal subjects and in patients with infections, nephrosis and hypocomplementaemic glomerulonephritis.
In normal subjects, factor B and C3b inactivator (KAF) levels were linearly related (r = 0-71); factor B levels in subjects with… 
Highly Cited
1975
Highly Cited
1975
Isolation and analysis of the mechanism of action of an inactivator of C4b in normal human serum
A complement regulatory principle, C4b inactivator, was isolated in a partially purified form from normal human serum. The C4b… 
1972
1972
C3b inactivator of man. 3. Further purification and production of antibody to C3b INA.
The C3b inactivator (C3bINA) contained in whole human serum has been purified by sequential diethylaminoethyl- and carboxymethyl…