Complement Factor I

Known as: Inactivator, Complement C4b-C3b, C4b-C3b Inactivator, Complement, Complement 3b Complement 4b Inactivator 
A plasma serine proteinase that cleaves the alpha-chains of C3b and C4b in the presence of the cofactors COMPLEMENT FACTOR H and C4-binding protein… (More)
National Institutes of Health

Related topics

Related topics

12 relations
CFI geneComplement C3 ConvertasesFibrinogenProcess of secretion
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Broader (2)

Complement 3b InactivatorsComplement Inactivating Agents

Papers overview

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2005
2005
Active-site peptide "fingerprinting" of glycosidases in complex mixtures by mass spectrometry. Discovery of a novel retaining beta-1,4-glycanase in Cellulomonas fimi.
New proteomics methods are required for targeting and identification of subsets of a proteome in an activity-based fashion. Here… (More)
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1986
1986
Binding of complement component C3b to glycoprotein gC of herpes simplex virus type 1: mapping of gC-binding sites and demonstration of conserved C3b binding in low-passage clinical isolates.
The sites on glycoprotein gC of herpes simplex virus type 1 (HSV-1) which bind complement component C3b were evaluated by using… (More)
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1985
1985
Binding of complement component C3b to glycoprotein C is modulated by sialic acid on herpes simplex virus type 1-infected cells.
Neuraminidase treatment of cells infected with herpes simplex virus type 1 (HSV-1) markedly enhanced the binding of complement… (More)
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Highly Cited
1980
Highly Cited
1980
Biosynthesis of the complement components and the regulatory proteins of the alternative complement pathway by human peripheral blood monocytes
Short-term cultures of human peripheral blood monocytes were shown to synthesize the alternative pathway complement components C3… (More)
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Highly Cited
1979
Highly Cited
1979
Modulation of the classical pathway C3 convertase by plasma proteins C4 binding protein and C3b inactivator.
We recently described the isolation from human serum of a serum protein (C4 binding protein) that functions as an essential… (More)
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Highly Cited
1978
Highly Cited
1978
Complement C3 convertase: cell surface restriction of beta1H control and generation of restriction on neuraminidase-treated cells.
The alternative or properdin pathway of complement is primarily controlled by the endopeptidase C3b inactivator (C3bINA) and the… (More)
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Highly Cited
1977
Highly Cited
1977
Human complement C3b inactivator: isolation, characterization, and demonstration of an absolute requirement for the serum protein beta1H for cleavage of C3b and C4b in solution
The complement regulatory enzyme, C3b inactivator (C3bINA), has been purified from human serum by affinity chromatography on an… (More)
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Highly Cited
1977
Highly Cited
1977
Activation of the alternative complement pathway due to resistance of zymosan-bound amplification convertase to endogenous regulatory mechanisms.
The surface of zymosan (Zy), by affording a protected microenvironment for C3b and the amplification convertase stabilized by… (More)
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Highly Cited
1976
Highly Cited
1976
Control of the amplification convertase of complement by the plasma protein beta1H.
An inhibitory activity for an erythrocyte in termediate bearing the properdin (P)-stabilized amplification C3 convertase, PC3bBb… (More)
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Highly Cited
1976
Highly Cited
1976
Modulation of the alternative complement pathways by beta 1 H globulin
C3b inactivator accelerator (A-C3bINA) was isolated from human plasma. An antiserum produced against the purified protein gave a… (More)
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