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Combinatorial Synthesis

Technique for making and testing many complex materials in parallel: computer guided synthesis in which all possible combinations are made… 
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Microfluidic platform for combinatorial synthesis and optimization of targeted nanoparticles for cancer therapy.
Taking a nanoparticle (NP) from discovery to clinical translation has been slow compared to small molecules, in part by the lack… 
Highly Cited
2012
Highly Cited
2012
Rapid and efficient ultrasound-assisted method for the combinatorial synthesis of spiro[indoline-3,4'-pyrano[2,3-c]pyrazole] derivatives.
An efficient one-pot synthesis of spiro[indoline-3,4'-pyrano[2,3-c]pyrazole] derivatives by four-component reaction of hydrazine… 
Review
2010
Review
2010
Solvothermal synthesis of perovskites and pyrochlores: crystallisation of functional oxides under mild conditions.
In this critical review we consider the large literature that has accumulated in the past 5-10 years concerning solution-mediated… 
Highly Cited
2009
Highly Cited
2009
Dynamic combinatorial synthesis of a catenane based on donor–acceptor interactions in water
A new type of neutral donor–acceptor [2]-catenane, containing both complementary units in the same ring was synthesized from a… 
Highly Cited
2008
Highly Cited
2008
Microwave-assisted combinatorial synthesis of hexa-substituted 1,4-dihydropyridines scaffolds using one-pot two-step multicomponent reaction followed by a S-alkylation.
A sequential one-pot two-step protocol for microwave-assisted synthesis of Hantzsch-type hexa-substituted 1,4-dihydropyridines… 
Highly Cited
2007
Highly Cited
2007
meso-Tetra(pentafluorophenyl)porphyrin as an efficient platform for combinatorial synthesis and the selection of new photodynamic therapeutics using a cancer cell line.
The four para fluoro groups on 5,10,15,20-tetrakis-(2,3,4,5,6-pentafluorophenyl)-porphyrin (TPPF20) are known to react with a… 
Review
2002
Review
2002
Exploring privileged structures: the combinatorial synthesis of cyclic peptides
Head-to-tail cyclic peptides have been reported to bind to multiple, unrelated classes of receptor with high affinity. They may… 
Highly Cited
2000
Highly Cited
2000
Target-Accelerated Combinatorial Synthesis and Discovery of Highly Potent Antibiotics Effective Against Vancomycin-Resistant Bacteria.
Biological activity can be predicted at a prescreening stage by using a target-accelerated combinatorial synthesis. The rate of… 
Highly Cited
1998
Highly Cited
1998
Carbohydrates as Multifunctional Chiral Scaffolds in Combinatorial Synthesis.
Four orthogonally stable protecting groups and a selectively cleavable anchor that are stable under basic conditions are required… 
Highly Cited
1994
Highly Cited
1994
The combinatorial synthesis and chemical and biological evaluation of a 1,4-benzodiazepine library.
A library of 192 structurally diverse 1,4-benzodiazepine derivatives containing a variety of chemical functionalities including… 
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