FAQ

Collagen Type I

Known as: Collagen I, Collagen 1, Collagen type 1 
A heterotrimeric fibrillar protein complex comprised of two collagen alpha-1(I) chains and one collagen alpha-2(I) chains. Type I collagen is the… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1972-2018
010020019722018

Related topics

Related topics

32 relations
Cell AdhesionCell MovementCollagen GeneCollagen Type V
(More)

Broader (3)

Fibrillar CollagenPerimysiumReticular layer of dermis

Narrower (3)

Procollagen Type Ialpha 2 collagen type Itype I collagen alpha 1

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Collagen Type I
Wound Healing
cell growth
physiological aspects
agonists
Cell Adhesion

Papers overview

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Highly Cited
2006
Highly Cited
2006
Effects of continuing or stopping alendronate after 5 years of treatment: the Fracture Intervention Trial Long-term Extension (FLEX): a randomized trial.
CONTEXT The optimal duration of treatment of women with postmenopausal osteoporosis is uncertain. OBJECTIVE To compare the… (More)
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Highly Cited
2004
Highly Cited
2004
Adhesion to Vitronectin and Collagen I Promotes Osteogenic Differentiation of Human Mesenchymal Stem Cells
The mechanisms controlling human mesenchymal stem cells (hMSC) differentiation are not entirely understood. We hypothesized that… (More)
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Highly Cited
2002
Highly Cited
2002
Mapping the ligand-binding sites and disease-associated mutations on the most abundant protein in the human, type I collagen.
Type I collagen is the most abundant protein in humans, and it helps to maintain the integrity of many tissues via its… (More)
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Highly Cited
2000
Highly Cited
2000
Regulation of Cell Invasion and Morphogenesis in a Three-Dimensional Type I Collagen Matrix by Membrane-Type Matrix Metalloproteinases 1, 2, and 3
During tissue-invasive events, migrating cells penetrate type I collagen-rich interstitial tissues by mobilizing undefined… (More)
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Highly Cited
2000
Highly Cited
2000
Type I collagen-induced osteoblastic differentiation of bone-marrow cells mediated by collagen-alpha2beta1 integrin interaction.
Bone marrow cells are multipotent cells. When bone marrow cells were cultured with type I collagen matrix gels, they showed high… (More)
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Highly Cited
1999
Highly Cited
1999
Vascular channel formation by human melanoma cells in vivo and in vitro: vasculogenic mimicry.
Tissue sections from aggressive human intraocular (uveal) and metastatic cutaneous melanomas generally lack evidence of… (More)
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Highly Cited
1997
Highly Cited
1997
The Activity of Collagenase-1 Is Required for Keratinocyte Migration on a Type I Collagen Matrix
We have shown in a variety of human wounds that collagenase-1 (MMP-1), a matrix metalloproteinase that cleaves fibrillar type I… (More)
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Highly Cited
1997
Highly Cited
1997
The human type I collagen mutation database
Type I collagen is the most abundant and ubiquitously distributed of the collagen family of proteins. It is a heterotrimer… (More)
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Highly Cited
1996
Highly Cited
1996
Reduced bone density and osteoporosis associated with a polymorphic Sp1 binding site in the collagen type I α 1 gene
Osteoporosis is a common disease with a strong genetic component1–3, characterized by reduced bone mass and increased fracture… (More)
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Highly Cited
1990
Highly Cited
1990
Radioimmunoassay of the carboxyterminal propeptide of human type I procollagen.
Type I collagen is the most abundant collagen type in soft tissues and the only type found in mineralized bone. We established a… (More)
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