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We describe a new computer program, SnpEff, for rapidly categorizing the effects of variants in genome sequences. Once a genome… Expand The identification of untranslated regions, introns, and coding regions within an organism remains challenging. We developed a… Expand MOTIVATION
The Glimmer gene-finding software has been successfully used for finding genes in bacteria, archaea and viruses… Expand We have systematically made a set of precisely defined, single‐gene deletions of all nonessential genes in Escherichia coli K‐12… Expand A potent retrovirus packaging cell line named Platinum-E (Plat-E) was generated based on the 293T cell line. Plat-E is superior… Expand Polypeptide chain elongation factor l a (EF-la) is an eukaryotic counterpart of E. coli EF-Tu which promotes the GTP-dependent… Expand Sequences flanking the AUG initiator codon influence its recognition by eukaryotic ribosomes. From a comparison of several… Expand By analyzing the effects of single base substitutions around the ATG initiator codon in a cloned preproinsulin gene, I have… Expand Sequences flanking the initiator codon in eukaryotic mRNAs are not random. Out of 153 messages examined, 151 have either a purine… Expand The complete sequence of the 16,295 bp mouse L cell mitochondrial DNA genome has been determined. Genes for the 12S and 16S… Expand