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The complete genome sequence of Escherichia coli K-12.
The 4,639,221-base pair sequence of Escherichia coli K-12 is presented. Of 4288 protein-coding genes annotated, 38 percent have no attributed function. Comparison with five other sequenced microbesExpand
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Mauve: multiple alignment of conserved genomic sequence with rearrangements.
As genomes evolve, they undergo large-scale evolutionary processes that present a challenge to sequence comparison not posed by short sequences. Recombination causes frequent genome rearrangements,Expand
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Extensive mosaic structure revealed by the complete genome sequence of uropathogenic Escherichia coli
We present the complete genome sequence of uropathogenic Escherichia coli, strain CFT073. A three-way genome comparison of the CFT073, enterohemorrhagic E. coli EDL933, and laboratory strain MG1655Expand
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On Differential Variability of Expression Ratios: Improving Statistical Inference about Gene Expression Changes from Microarray Data
We consider the problem of inferring fold changes in gene expression from cDNA microarray data. Standard procedures focus on the ratio of measured fluorescent intensities at each spot on theExpand
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Emergent Properties of Reduced-Genome Escherichia coli
With the use of synthetic biology, we reduced the Escherichia coli K-12 genome by making planned, precise deletions. The multiple-deletion series (MDS) strains, with genome reductions up to 15%, wereExpand
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Molecular Evolution of a Pathogenicity Island from Enterohemorrhagic Escherichia coli O157:H7
ABSTRACT We report the complete 43,359-bp sequence of the locus of enterocyte effacement (LEE) from EDL933, an enterohemorrhagicEscherichia coli O157:H7 serovar originally isolated from contaminatedExpand
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Functional genomics: expression analysis of Escherichia coli growing on minimal and rich media.
DNA arrays of the entire set of Escherichia coli genes were used to measure the genomic expression patterns of cells growing in late logarithmic phase on minimal glucose medium and on Luria brothExpand
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Escherichia coli K-12: a cooperatively developed annotation snapshot—2005
The goal of this group project has been to coordinate and bring up-to-date information on all genes of Escherichia coli K-12. Annotation of the genome of an organism entails identification of genes,Expand
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Genome sequence of Yersinia pestis KIM.
We present the complete genome sequence of Yersinia pestis KIM, the etiologic agent of bubonic and pneumonic plague. The strain KIM, biovar Mediaevalis, is associated with the second pandemic,Expand
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Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18.
We present the 4.8-Mb complete genome sequence of Salmonella enterica serovar Typhi strain Ty2, a human-specific pathogen causing typhoid fever. A comparison with the genome sequence of recentlyExpand
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