FAQ

Cobblestone Area-Forming Cells

Known as: CAFC, Cobble Stone Area-Forming Cells, Cobblestone Forming Units 
The number of hematopoietic stem cells (HSCs) that migrate between or beneath a co-cultured feeder cell layer and become trapped. When HSCs are… (More)

Topic mentions per year

Topic mentions per year

1985-2017
05101519852017

Papers overview

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2008
2008
In vitro assays for cobblestone area-forming cells, LTC-IC, and CFU-C.
Various assays exist that measure the function of hematopoietic stemcells (HSCs). In this chapter, in vitro assays are described… (More)
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Highly Cited
2005
Highly Cited
2005
Haploinsufficiency of GATA-2 perturbs adult hematopoietic stem-cell homeostasis.
The zinc finger transcription factor GATA-2 plays a fundamental role in generating hematopoietic stem-cells in mammalian… (More)
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2002
2002
The cobblestone-area-forming cell assay.
Hematopoietic stem cell (HSC) subsets are defined by the capacity to which their offspring can contribute to the various mature… (More)
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Highly Cited
1999
Highly Cited
1999
Dynamic changes in mouse hematopoietic stem cell numbers during aging.
To address the fundamental question of whether or not stem cell populations age, we performed quantitative measurements of the… (More)
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1998
1998
Highly efficient transduction of the green fluorescent protein gene in human umbilical cord blood stem cells capable of cobblestone formation in long-term cultures and multilineage engraftment of…
Purified CD34(+) and CD34(+)CD38(-) human umbilical cord blood (UCB) cells were transduced with the recombinant variant of… (More)
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1997
1997
Efficient long-term maintenance of chronic myeloid leukemic cobblestone area forming cells on a murine stromal cell line
Stroma-supported long-term cultures (LTC) of chronic myeloid leukemia (CML) progenitor cells have previously revealed differences… (More)
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Highly Cited
1997
Highly Cited
1997
Mouse strain-dependent changes in frequency and proliferation of hematopoietic stem cells during aging: correlation between lifespan and cycling activity.
We have quantified the frequency and proliferation of five subsets of primitive hematopoietic cells, using the cobblestone area… (More)
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1996
1996
Quantitative analysis of cobblestone area-forming cells in bone marrow of patients with aplastic anemia by limiting dilution assay.
In the past, the analysis of primitive human hematopoietic progenitor cells with repopulating activity was limited by lack of… (More)
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Highly Cited
1994
Highly Cited
1994
Frequency analysis of human primitive haematopoietic stem cell subsets using a cobblestone area forming cell assay.
Stroma-dependent long-term bone marrow cultures (LTBMC) assay the ability of primitive haematopoietic stem cells (HSC) for long… (More)
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Highly Cited
1991
Highly Cited
1991
Use of limiting-dilution type long-term marrow cultures in frequency analysis of marrow-repopulating and spleen colony-forming hematopoietic stem cells in the mouse.
We have developed an in vitro clonal assay of murine hematopoietic precursor cells that form spleen colonies (CFU-S day 12) or… (More)
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