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Cobblestone Area-Forming Cells

Known as: CAFC, Cobble Stone Area-Forming Cells, Cobblestone Forming Units 
The number of hematopoietic stem cells (HSCs) that migrate between or beneath a co-cultured feeder cell layer and become trapped. When HSCs are… 
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
In vitro assays for cobblestone area-forming cells, LTC-IC, and CFU-C.
Various assays exist that measure the function of hematopoietic stemcells (HSCs). In this chapter, in vitro assays are described… 
2007
2007
Microencapsulated feeder cells as a source of soluble factors for expansion of CD34(+) hematopoietic stem cells.
Highly Cited
2001
Highly Cited
2001
The dynamics of bone marrow stromal cells in the proliferation of multipotent hematopoietic progenitors by substance P: an understanding of the effects of a neurotransmitter on the differentiating…
1999
1999
Large scale recovery and characterization of stromal cell-associated primitive haemopoietic progenitor cells from filter-retained human bone marrow
Bone marrow aspirates are composed of two cellular compartments, an abundant buffy coat suspension and a minor particulate… 
1999
1999
Short-term, serum-free, static culture of cord blood-derived CD34+ cells: effects of FLT3-L and MIP-1alpha on in vitro expansion of hematopoietic progenitor cells.
BACKGROUND AND OBJECTIVE The use of ex vivo expanded cells has been suggested as a possible means to accelerate the speed of… 
1997
1997
Efficient long-term maintenance of chronic myeloid leukemic cobblestone area forming cells on a murine stromal cell line
Stroma-supported long-term cultures (LTC) of chronic myeloid leukemia (CML) progenitor cells have previously revealed differences… 
1996
1996
Frequency analysis of multidrug resistance-1 gene transfer into human primitive hematopoietic progenitor cells using the cobblestone area-forming cell assay and detection of vector-mediated P…
Transfer of the multidrug resistance-1 (MDR1) gene into hematopoietic progenitor cells may reduce myelotoxicity of MDR1-related… 
1994
1994
Contractile arrest increases sarcoplasmic reticulum calcium uptake and SERCA2 gene expression in cultured neonatal rat heart cells.
We developed protocols with intact cultured neonatal rat myocytes to directly evaluate the function of the sarcoplasmic reticulum… 
Highly Cited
1993
Highly Cited
1993
Quantitation of murine hematopoietic stem cells in vitro by limiting dilution analysis of cobblestone area formation on a clonal stromal cell line.
Murine hematopoietic stem cells with varying proliferative capacity can be assayed by limiting dilution analysis of "cobblestone… 
Highly Cited
1992
Highly Cited
1992
Murine haemopoietic stem cells with long-term engraftment and marrow repopulating ability are more resistant to gamma-radiation than are spleen colony forming cells.
The radiation sensitivity of various subsets in the haemopoietic stem cell hierarchy was defined using a limiting dilution type… 
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