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Cobblestone Area-Forming Cells
Known as:
CAFC
, Cobble Stone Area-Forming Cells
, Cobblestone Forming Units
The number of hematopoietic stem cells (HSCs) that migrate between or beneath a co-cultured feeder cell layer and become trapped. When HSCs are…
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National Institutes of Health
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
In vitro assays for cobblestone area-forming cells, LTC-IC, and CFU-C.
R. van Os
,
B. Dethmers-Ausema
,
G. de Haan
Methods in molecular biology
2008
Corpus ID: 21527321
Various assays exist that measure the function of hematopoietic stemcells (HSCs). In this chapter, in vitro assays are described…
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2007
2007
Microencapsulated feeder cells as a source of soluble factors for expansion of CD34(+) hematopoietic stem cells.
N. Fujimoto
,
S. Fujita
,
+4 authors
H. Iwata
Biomaterials
2007
Corpus ID: 38548156
Highly Cited
2001
Highly Cited
2001
The dynamics of bone marrow stromal cells in the proliferation of multipotent hematopoietic progenitors by substance P: an understanding of the effects of a neurotransmitter on the differentiating…
P. Rameshwar
,
G. Zhu
,
+5 authors
P. Gascón
Journal of Neuroimmunology
2001
Corpus ID: 24914144
1999
1999
Large scale recovery and characterization of stromal cell-associated primitive haemopoietic progenitor cells from filter-retained human bone marrow
I. Blazsek
,
B. D. Marsalet
,
S. Legras
,
S. Marion
,
D. Machover
,
Misset Jl
Bone Marrow Transplantation
1999
Corpus ID: 12575282
Bone marrow aspirates are composed of two cellular compartments, an abundant buffy coat suspension and a minor particulate…
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1999
1999
Short-term, serum-free, static culture of cord blood-derived CD34+ cells: effects of FLT3-L and MIP-1alpha on in vitro expansion of hematopoietic progenitor cells.
G. Capmany
,
Sergi Querol
,
J. Cancelas
,
Joan García
Haematologica
1999
Corpus ID: 20513326
BACKGROUND AND OBJECTIVE The use of ex vivo expanded cells has been suggested as a possible means to accelerate the speed of…
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1997
1997
Efficient long-term maintenance of chronic myeloid leukemic cobblestone area forming cells on a murine stromal cell line
J. Cornelissen
,
A. Wognum
,
+4 authors
B. Löwenberg
Leukemia
1997
Corpus ID: 24409592
Stroma-supported long-term cultures (LTC) of chronic myeloid leukemia (CML) progenitor cells have previously revealed differences…
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1996
1996
Frequency analysis of multidrug resistance-1 gene transfer into human primitive hematopoietic progenitor cells using the cobblestone area-forming cell assay and detection of vector-mediated P…
S. Fruehauf
,
D. Breems
,
+7 authors
J. Boesen
Human Gene Therapy
1996
Corpus ID: 46315396
Transfer of the multidrug resistance-1 (MDR1) gene into hematopoietic progenitor cells may reduce myelotoxicity of MDR1-related…
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1994
1994
Contractile arrest increases sarcoplasmic reticulum calcium uptake and SERCA2 gene expression in cultured neonatal rat heart cells.
J. W. Bassani
,
M. Qi
,
A. Samarel
,
D. Bers
Circulation Research
1994
Corpus ID: 6869474
We developed protocols with intact cultured neonatal rat myocytes to directly evaluate the function of the sarcoplasmic reticulum…
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Highly Cited
1993
Highly Cited
1993
Quantitation of murine hematopoietic stem cells in vitro by limiting dilution analysis of cobblestone area formation on a clonal stromal cell line.
S. Neben
,
P. Anklesaria
,
J. Greenberger
,
P. Mauch
Experimental Hematology
1993
Corpus ID: 30140783
Murine hematopoietic stem cells with varying proliferative capacity can be assayed by limiting dilution analysis of "cobblestone…
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Highly Cited
1992
Highly Cited
1992
Murine haemopoietic stem cells with long-term engraftment and marrow repopulating ability are more resistant to gamma-radiation than are spleen colony forming cells.
R. Ploemacher
,
R. Os
,
C. A. J. Beurden
,
Julian D. Down
International Journal of Radiation Biology
1992
Corpus ID: 20825582
The radiation sensitivity of various subsets in the haemopoietic stem cell hierarchy was defined using a limiting dilution type…
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