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Veto-Like Activity of Mesenchymal Stem Cells: Functional Discrimination Between Cellular Responses to Alloantigens and Recall Antigens1
It was shown that MSC could blunt the cytotoxic effects of allogeneic-induced effectors to mitogen-activated targets, and exerted veto-like activity, but caused no effect on responses to recall Ags. Expand
Oxygen saturation in the bone marrow of healthy volunteers.
In recent years there has been a great deal of progress in understanding the homeostasis of different tissue microenvironments, and this has been particularly true of the hematopoietic system.Expand
Antigen-presenting property of mesenchymal stem cells occurs during a narrow window at low levels of interferon-gamma.
Ex vivo and low levels of IFNgamma are required for MHC-II expression on MSCs, and for APC functions, and the study has implications for BM protection against infection and exacerbated inflammatory responses. Expand
Mesenchymal Stem Cells Protect Breast Cancer Cells through Regulatory T Cells: Role of Mesenchymal Stem Cell-Derived TGF-β
Two studies show an MSC-mediated increase in Tregs in cocultures of PBMCs and BCCs, and the reduction in immune cell proliferation and recruitment mediated by MSCs has implications for treatment of breast cancer with chemotherapy. Expand
Delivery of Functional Anti-miR-9 by Mesenchymal Stem Cell–derived Exosomes to Glioblastoma Multiforme Cells Conferred Chemosensitivity
A potential role for MSCs in the functional delivery of synthetic anti-miR-9 to reverse the chemoresistance of GBM cells was shown. Expand
Gap junction-mediated import of microRNA from bone marrow stromal cells can elicit cell cycle quiescence in breast cancer cells.
It is shown that the transfer of miRNAs from BM stroma to BC cells might play a role in the dormancy of BM metastases, leading to reduced CXCL12 levels and decreased proliferation. Expand
Functional Similarities Among Genes Regulated by Oct4 in Human Mesenchymal and Embryonic Stem Cells
It is shown that OCT4 provides similar regulatory circuitries in human MSCs and ESCs, using chromatin immunoprecipitation‐DNA selection and ligation technology and loss‐of‐function studies and the results suggest similar regulatory mechanisms for OCT4 in M SCs and Escs and have implications regarding MSC plasticity. Expand
Mesenchymal Stem Cell-Derived Exosomes Stimulate Cycling Quiescence and Early Breast Cancer Dormancy in Bone Marrow.
It is reported that breast cancer cells prime MSC to release exosomes containing distinct miRNA contents, such as miR-222/223, which in turn promotes quiescence in a subset of cancer cells and confers drug resistance. Expand
Bone Marrow Failure Following Severe Injury in Humans
Erythropoietin levels are preserved following trauma, implying that the persistent anemia of injury is related to the failure of the bone marrow to respond to erythropoetin. Expand
Brain‐derived neurotrophic factor facilitates maturation of mesenchymal stem cell‐derived dopamine progenitors to functional neurons
The role of brain‐derived neurotrophic factor (BDNF) in the maturation of the MSC‐derived DA progenitors is reported, and it is demonstrated that 9‐day induced MSCs show significant tropomyosin‐receptor‐kinase B expression, which correlate with its ligand, BDNF, being able to induce functional maturation. Expand