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Cleavage Stimulation Factor

Known as: Cleavage Stimulation Factor [Chemical/Ingredient], CstF Protein 
A RNA-binding protein that stimulates the cleavage of the 3' end of MRNA near the POLYADENYLATION site. It is a heterotrimer of 55-, 64- and 77-kDa… Expand
National Institutes of Health

Related topics

Related topics

10 relations
CSTF2 geneCSTF2T geneIn BloodProcess of secretion
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Papers overview

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Highly Cited
2012
Highly Cited
2012
Cleavage factor Im is a key regulator of 3' UTR length.
In eukaryotes, the 3' ends of RNA polymerase II-transcribed RNAs are generated in the majority of cases by site-specific… Expand
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Highly Cited
2009
Highly Cited
2009
The tumor suppressor Cdc73 functionally associates with CPSF and CstF 3' mRNA processing factors.
The CDC73 tumor suppressor gene is mutationally inactivated in hereditary and sporadic parathyroid tumors. Its product, the Cdc73… Expand
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Highly Cited
2007
Highly Cited
2007
Loss of polyadenylation protein tauCstF-64 causes spermatogenic defects and male infertility.
Polyadenylation, the process of eukaryotic mRNA 3' end formation, is essential for gene expression and cell viability… Expand
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Highly Cited
2005
Highly Cited
2005
Symplekin and multiple other polyadenylation factors participate in 3'-end maturation of histone mRNAs.
Most metazoan messenger RNAs encoding histones are cleaved, but not polyadenylated at their 3' ends. Processing in mammalian cell… Expand
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Highly Cited
2001
Highly Cited
2001
Capping, splicing, and 3' processing are independently stimulated by RNA polymerase II: different functions for different segments of the CTD.
Capping, splicing, and cleavage/polyadenylation of pre-mRNAs are interdependent events that are all stimulated in vivo by the… Expand
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Highly Cited
2000
Highly Cited
2000
Complex protein interactions within the human polyadenylation machinery identify a novel component.
Polyadenylation of mRNA precursors is a two-step reaction requiring multiple protein factors. Cleavage stimulation factor (CstF… Expand
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2000
2000
The Drosophila homologue of the 64 kDa subunit of cleavage stimulation factor interacts with the 77 kDa subunit encoded by the suppressor of forked gene.
During mRNA 3' end formation, cleavage stimulation factor (CstF) binds to a GU-rich sequence downstream from the polyadenylation… Expand
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Highly Cited
1998
Highly Cited
1998
Levels of polyadenylation factor CstF-64 control IgM heavy chain mRNA accumulation and other events associated with B cell differentiation.
Cleavage stimulation factor (CstF) is one of the multiple factors required for mRNA polyadenylation. The concentration of one… Expand
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Highly Cited
1996
Highly Cited
1996
Purification and characterization of human cleavage factor Im involved in the 3' end processing of messenger RNA precursors.
Six different protein factors are required for the specific cleavage and polyadenylation of pre-mRNA in mammals. Whereas four of… Expand
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Highly Cited
1996
Highly Cited
1996
The RNA 3' cleavage factors CstF 64 kDa and CPSF 100 kDa are concentrated in nuclear domains closely associated with coiled bodies and newly synthesized RNA.
The cleavage stimulation factor (CstF), and the cleavage and polyadenylation specificity factor (CPSF) are necessary for 3… Expand
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