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Common SNP in pre-miR-146a decreases mature miR expression and predisposes to papillary thyroid carcinoma
Although papillary thyroid carcinoma (PTC) displays strong heritability, no predisposing germ-line mutations have been found. We show that a common G/C polymorphism (rs2910164) within theExpand
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Regulation of cytoplasmic mRNA decay
Discoveries made over the past 20 years highlight the importance of mRNA decay as a means of modulating gene expression and thereby protein production. Up until recently, studies largely focused onExpand
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A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay
4E-transporter (4E-T) is one of several proteins that bind the mRNA 5′cap-binding protein, eukaryotic initiation factor 4E (eIF4E), through a conserved binding motif. We previously showed that 4E-TExpand
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RNA helicase A is necessary for translation of selected messenger RNAs
RNA helicase A (RHA) is a highly conserved DEAD-box protein that activates transcription, modulates RNA splicing and binds the nuclear pore complex. The life cycle of typical mRNA involves RNAExpand
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Regulation of cytoplasmic mRNA decay
Nature Reviews Genetics 13, 246–259 (2012) In panel a of the figure in Box 1 of the above article, the labels for the exonuclease activities were reversed. The figure has now been corrected online.Expand
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Mycobacterium tuberculosis lipomannan blocks TNF biosynthesis by regulating macrophage MAPK-activated protein kinase 2 (MK2) and microRNA miR-125b
Contact of Mycobacterium tuberculosis (M.tb) with the immune system requires interactions between microbial surface molecules and host pattern recognition receptors. Major M.tb-exposed cell envelopeExpand
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Polysome-Bound Endonuclease PMR1 Is Targeted to Stress Granules via Stress-Specific Binding to TIA-1
ABSTRACT The generalized process of mRNA decay involves deadenylation followed by release from translating polysomes, decapping, and exonuclease decay of the mRNA body. In contrast the mRNAExpand
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A polysomal ribonuclease involved in the destabilization of albumin mRNA is a novel member of the peroxidase gene family.
We have purified an approximately 60 kDa endoribonuclease from Xenopus liver polysomes with properties expected for a messenger RNase involved in the estrogen-regulated destabilization of serumExpand
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Identification of a Cytoplasmic Complex That Adds a Cap onto 5′-Monophosphate RNA
ABSTRACT Endonuclease decay of nonsense-containing β-globin mRNA in erythroid cells generates 5′-truncated products that were reported previously to have a cap or caplike structure. We confirmed thatExpand
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New Ways of Initiating Translation in Eukaryotes?
This letter to the editor is a response by a large number of investigators in the field of protein synthesis to the minireview published by Dr. Kozak in Molecular and Cellular Biology (9). ThisExpand
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