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Sirt1 Regulates Aging and Resistance to Oxidative Stress in the Heart
Silent information regulator (Sir)2, a class III histone deacetylase, mediates lifespan extension in model organisms and prevents apoptosis in mammalian cells. However, beneficial functions of Sir2Expand
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Mutant p53 Disrupts Mammary Tissue Architecture via the Mevalonate Pathway
p53 is a frequent target for mutation in human tumors, and mutant p53 proteins can actively contribute to tumorigenesis. We employed a three-dimensional culture model in which nonmalignant breastExpand
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Progressive lengthening of 3′ untranslated regions of mRNAs by alternative polyadenylation during mouse embryonic development
The 3′ untranslated regions (3′ UTRs) of mRNAs contain cis-acting elements for posttranscriptional regulation of gene expression. Here, we report that mouse genes tend to express mRNAs with longer 3′Expand
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Analysis of alterative cleavage and polyadenylation by 3′ region extraction and deep sequencing
Alternative cleavage and polyadenylation (APA) generates diverse mRNA isoforms. We developed 3′ region extraction and deep sequencing (3′READS) to address mispriming issues that commonly plagueExpand
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Alternative cleavage and polyadenylation: the long and short of it.
Cleavage and polyadenylation (C/P) of nascent transcripts is essential for maturation of the 3' ends of most eukaryotic mRNAs. Over the past three decades, biochemical studies have elucidated theExpand
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Signals for pre‐mRNA cleavage and polyadenylation
  • B. Tian, J. Graber
  • Biology, Medicine
  • Wiley interdisciplinary reviews. RNA
  • 1 May 2012
Pre‐mRNA cleavage and polyadenylation is an essential step for 3′ end formation of almost all protein‐coding transcripts in eukaryotes. The reaction, involving cleavage of nascent mRNA followed byExpand
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Systematic Analysis of Cis-Elements in Unstable mRNAs Demonstrates that CUGBP1 Is a Key Regulator of mRNA Decay in Muscle Cells
Background Dramatic changes in gene expression occur in response to extracellular stimuli and during differentiation. Although transcriptional effects are important, alterations in mRNA decay alsoExpand
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Reprogramming of 3′ Untranslated Regions of mRNAs by Alternative Polyadenylation in Generation of Pluripotent Stem Cells from Different Cell Types
Background The 3′ untranslated regions (3′UTRs) of mRNAs contain cis elements involved in post-transcriptional regulation of gene expression. Over half of all mammalian genes contain multipleExpand
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Characterization of the mouse IFN-lambda ligand-receptor system: IFN-lambdas exhibit antitumor activity against B16 melanoma.
Recently discovered type III IFNs (IFN-lambda) exert their antiviral and immunomodulatory activities through a unique receptor complex composed of IFN-lambdaR1 and interleukin-10 receptor 2. ToExpand
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Association between gene expression profile and tumor invasion in oral squamous cell carcinoma.
There are limited studies attempting to correlate the expression changes in oral squamous cell carcinoma with clinically relevant variables. We determined the gene expression profile of 16 tumor andExpand
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