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Chronic granulomatous disease

Known as: Chronic Granulomatous Diseases, Granulomatous Diseases, Chronic, CGD 
A rare genetic disorder with a predominantly X-linked recessive pattern of inheritance resulting in impaired phagocytic clearance of bacteria and… 
National Institutes of Health

Related topics

Related topics

15 relations
Chronic diseaseFMN reductaseGranulomatous Disease, Chronic, X-LinkedIn Blood

Narrower (3)

Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-NegativeGranulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type IGranulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type II

Broader (1)

Phagocyte Bactericidal Dysfunction

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2008
Review
2008
Inflammatory Manifestations in Chronic Granulomatous Disease (CGD)
Chronic granulomatous disease (CGD) is a genetically heterogeneous disease characterized by recurrent life-threatening infections… 
Review
2006
Review
2006
Genotoxicity of retroviral integration in hematopoietic cells.
Review
2003
Review
2003
Oxidative killing of microbes by neutrophils.
Highly Cited
1997
Highly Cited
1997
Absence of Respiratory Burst in X-linked Chronic Granulomatous Disease Mice Leads to Abnormalities in Both Host Defense and Inflammatory Response to Aspergillus fumigatus
Mice with X-linked chronic granulomatous disease (CGD) generated by targeted disruption of the gp91phox subunit of the NADPH… 
Highly Cited
1994
Highly Cited
1994
Rac translocates independently of the neutrophil NADPH oxidase components p47phox and p67phox. Evidence for its interaction with flavocytochrome b558.
Review
1991
Review
1991
Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1
PROFESSIONAL phagocytes, such as neutrophils and monocytes, have an NADPH oxidase that generates superoxide and other reduced… 
Highly Cited
1989
Highly Cited
1989
Recombinant 47-kilodalton cytosol factor restores NADPH oxidase in chronic granulomatous disease.
A 47-kilodalton neutrophil cytosol factor (NCF-47k), required for activation of nicotinamide adenine dinucleotide phosphate… 
Highly Cited
1989
Highly Cited
1989
Genetic variants of chronic granulomatous disease: prevalence of deficiencies of two cytosolic components of the NADPH oxidase system.
Chronic granulomatous disease, a syndrome of recurrent infections and failure of oxidative microbicidal activity in phagocytes… 
Highly Cited
1987
Highly Cited
1987
Absence of both cytochrome b−245 subunits from neutrophils in X-linked chronic granulomatous disease
Phagocytosis by neutrophils and other 'professional' phagocytic cells is accompanied by a microbicidal burst of non-mitochondrial… 
Review
1986
Review
1986
Bifunctional messenger RNAs in eukaryotes
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