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Chromosome Breakpoints

Known as: Breakpoint, Chromosome, Breakpoints, Chromosome, Chromosome Breakpoint 
The locations in specific DNA sequences where CHROMOSOME BREAKS have occurred.
National Institutes of Health

Related topics

Related topics

1 relation
aspects of radiation effects

Papers overview

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Highly Cited
2009
Highly Cited
2009
Distinct retroelement classes define evolutionary breakpoints demarcating sites of evolutionary novelty
BackgroundLarge-scale genome rearrangements brought about by chromosome breaks underlie numerous inherited diseases, initiate or… 
Highly Cited
2005
Highly Cited
2005
Position effects due to chromosome breakpoints that map approximately 900 Kb upstream and approximately 1.3 Mb downstream of SOX9 in two patients with campomelic dysplasia.
Campomelic dysplasia (CD) is a semilethal skeletal malformation syndrome with or without XY sex reversal. In addition to the… 
Highly Cited
2003
Highly Cited
2003
Combined 24-color karyotyping and comparative genomic hybridization analysis indicates predominant rearrangements of early replicating chromosome regions in neuroblastoma.
Highly Cited
2001
Highly Cited
2001
Germ line insertion of mtDNA at the breakpoint junction of a reciprocal constitutional translocation
Abstract. Constitutional chromosomal translocations are relatively common causes of human morbidity, yet the DNA double-strand… 
Highly Cited
2000
Highly Cited
2000
Intronic U50 small‐nucleolar‐RNA (snoRNA) host gene of no protein‐coding potential is mapped at the chromosome breakpoint t(3;6)(q27;q15) of human B‐cell lymphoma
In eukaryotic cells, nucleolar processing of preribosomal RNAs (prerRNAs) is assisted by a large number of small nucleolar RNAs… 
Highly Cited
1999
Highly Cited
1999
Chromosome abnormalities in ovarian adenocarcinoma: I. nonrandom chromosome abnormalities from 244 cases
Cytogenetics provides important insights into the molecular pathogenesis of human cancers. Although extensive data exist on… 
Highly Cited
1995
Highly Cited
1995
Mapping the X chromosome breakpoint in two papillary renal cell carcinoma cell lines with a t(X;1)(p11.2;q21.2) and the first report of a female case.
A t(X;1)(p11.2;q21.2) has been reported in cases of papillary renal cell tumors arising in males. In this study two cell lines… 
Highly Cited
1992
Highly Cited
1992
Cloning and characterization of chromosome breakpoints of Plasmodium falciparum: breakage and new telomere formation occurs frequently and randomly in subtelomeric genes.
We analysed the genetic stability of two subtelomeric genes of the human malaria parasite Plasmodium falciparum. A PCR based… 
Highly Cited
1988
Highly Cited
1988
Thermostable DNA polymerase chain amplification of t(14;18) chromosome breakpoints and detection of minimal residual disease.
Achieving the capacity to detect minimal numbers of neoplastic cells is a major cancer diagnostic challenge. Chromosomal… 
Highly Cited
1986
Highly Cited
1986
Heterogeneity of chromosome 22 breakpoint in Philadelphia-positive (Ph+) acute lymphocytic leukemia.
In chronic myelogenous leukemias (CML) with the t(9;22)(q34;q11) chromosome translocation the breakpoints on chromosome 22 occur… 
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