Chromosome Breakage

Known as: establishment or maintenance of heterochromatin architecture, Breakage, Chromosomal, High frequency of chromosome breaks in lymphocytes 
Regulated cleavage of the developing macronuclear genome at a limited number of chromosome breakage sites (CBS). The macronuclear destined segment… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1938-2017
020406019382016

Papers overview

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Highly Cited
2012
Highly Cited
2012
Characterization of the prostate cancer transcriptome and genome has identified chromosomal rearrangements and copy number gains… (More)
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Highly Cited
2011
Highly Cited
2011
Clustered DNA damage induced by ionizing radiation is refractory to repair and may trigger carcinogenic events for reasons that… (More)
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Highly Cited
2007
Highly Cited
2007
DNA double-strand break (DSB) repair and checkpoint control represent distinct mechanisms to reduce chromosomal instability… (More)
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Highly Cited
2007
Highly Cited
2007
Common fragile sites are regions of human chromosomes prone to breakage. Fragile site FRA16D spans the WWOX/FOR tumor suppressor… (More)
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Highly Cited
2006
Highly Cited
2006
During anaphase, spindle elongation pulls sister chromatids apart until each pair is fully separated. In turn, cytokinesis… (More)
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Highly Cited
2004
Highly Cited
2004
Adeno-associated virus (AAV) vectors transduce cells by multiple pathways, including integration at nonhomologous chromosomal… (More)
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Highly Cited
2000
Highly Cited
2000
Cancer-causing mutations often arise from gross chromosomal rearrangements (GCRs) such as translocations, which involve genetic… (More)
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Highly Cited
1999
Highly Cited
1999
Women heterozygous for mutations in the breast-cancer susceptibility genes BRCA1 and BRCA2 have a highly elevated risk of… (More)
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Highly Cited
1997
Highly Cited
1997
Folate deficiency causes massive incorporation of uracil into human DNA (4 million per cell) and chromosome breaks. The likely… (More)
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Highly Cited
1989
Highly Cited
1989
The hypothesis that DNA topoisomerase II facilitates the separation of replicated sister chromatids was tested by examining the… (More)
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