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Cholesterol 7-alpha-Monooxygenase

Known as: Cytochrome P-450 CYP7, Cholesterol 7-alpha-Hydroxylase, Cholesterol-7-Hydroxylase 
A membrane-bound cytochrome P450 enzyme that catalyzes the 7-alpha-hydroxylation of CHOLESTEROL in the presence of molecular oxygen and NADPH… 
National Institutes of Health

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Related topics

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7alpha hydroxylaseIn BloodProcess of secretionantagonists & inhibitors

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CYP7A1 protein, human

Papers overview

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Highly Cited
2006
Highly Cited
2006
Hypocholesterolemic action of pre-germinated brown rice in hepatoma-bearing rats.
Highly Cited
2005
Highly Cited
2005
Synthetic LXR agonists increase LDL in CETP species Published, JLR Papers in Press, July 16, 2005. DOI 10.1194/jlr.M500116-JLR200
Liver X receptor (LXR) nuclear receptors regulate the expression of genes involved in whole body cholesterol trafficking… 
Highly Cited
2000
Highly Cited
2000
Down-regulation of intestinal scavenger receptor class B, type I (SR-BI) expression in rodents under conditions of deficient bile delivery to the intestine.
Scavenger receptor class B, type I (SR-BI) is expressed in the intestines of rodents and has been suggested to be involved in the… 
Highly Cited
1999
Highly Cited
1999
Phenotypic characterization of Lith genes that determine susceptibility to cholesterol cholelithiasis in inbred mice: integrated activities of hepatic lipid regulatory enzymes.
There is no consensus whether hepatic lipid regulatory enzymes play primary or secondary roles in cholesterol cholelithiasis. We… 
1999
1999
Differential effects of 17alpha-ethinylestradiol on the neutral and acidic pathways of bile salt synthesis in the rat.
Effects of 17alpha-ethinylestradiol (EE) on the neutral and acidic biosynthetic pathways of bile salt (BS) synthesis were… 
Highly Cited
1994
Highly Cited
1994
Effect of squalene synthase inhibition on the expression of hepatic cholesterol biosynthetic enzymes, LDL receptor, and cholesterol 7 alpha hydroxylase.
Squalene synthase catalyzes the committed step in the biosynthesis of sterols. Treating rats with zaragozic acid A, a potent… 
Highly Cited
1981
Highly Cited
1981
Reversible activation-inactivation of cholesterol 7alpha-hydroxylase possibly due to phosphorylation-dephosphorylation.
1979
1979
Influence of whole or skim milk on cholesterol metabolism in rats.
Male Wistar rats were fed commercial ration and given whole milk, skim milk, or water to drink. After 3 weeks the control group… 
Highly Cited
1978
Highly Cited
1978
The submicrosomal localization of 3-hydroxy-3-methylglutaryl-coenzyme-A reductase, cholesterol 7alpha-hydroxylase and cholesterol in rat liver.
In order to determine the submicrosomal distribution of cholesterol 7α-hydroxylase, 3-hydroxy-3-methylglutaryl-coenzyme-A… 
1973
1973
Studies on the formation of C7-oxygenated cholesterol and beta-sitosterol metabolites in cell-free preparations of rat liver.
The microsomal fraction and the 18,000 g supernatant fluid obtained from livers from normal rats, cholestyraminetreated rats, or… 
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