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Cholesterol 7-alpha-Monooxygenase

Known as: Cytochrome P-450 CYP7, Cholesterol 7-alpha-Hydroxylase, Cholesterol-7-Hydroxylase 
A membrane-bound cytochrome P450 enzyme that catalyzes the 7-alpha-hydroxylation of CHOLESTEROL in the presence of molecular oxygen and NADPH… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2009
Review
2009
  • J. Chiang
  • Journal of Lipid Research
  • 2009
  • Corpus ID: 22002741
Bile acids are physiological detergents that generate bile flow and facilitate intestinal absorption and transport of lipids… Expand
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Highly Cited
2005
Highly Cited
2005
The liver and intestine play crucial roles in maintaining bile acid homeostasis. Here, we demonstrate that fibroblast growth… Expand
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Review
2005
Review
2005
Drug metabolizing enzymes (DMEs) play central roles in the metabolism, elimination and detoxification of xenobiotics and drugs… Expand
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Highly Cited
2001
Highly Cited
2001
The pregnane X receptor (PXR) is the molecular target for catatoxic steroids such as pregnenolone 16α-carbonitrile (PCN), which… Expand
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Highly Cited
2000
Highly Cited
2000
The catabolism of cholesterol into bile acids is regulated by oxysterols and bile acids, which induce or repress transcription of… Expand
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Highly Cited
2000
Highly Cited
2000
Mice lacking the nuclear bile acid receptor FXR/BAR developed normally and were outwardly identical to wild-type littermates. FXR… Expand
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Highly Cited
1999
Highly Cited
1999
Bile acids are essential for the solubilization and transport of dietary lipids and are the major products of cholesterol… Expand
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Review
1999
Review
1999
  • D. Waxman
  • Archives of biochemistry and biophysics
  • 1999
  • Corpus ID: 26056207
The biochemistry of foreign compound metabolism and the roles played by individual cytochrome P450 (CYP) enzymes in drug… Expand
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Highly Cited
1998
Highly Cited
1998
We demonstrate that mice lacking the oxysterol receptor, LXR alpha, lose their ability to respond normally to dietary cholesterol… Expand
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Highly Cited
1997
Highly Cited
1997
Accumulation of cholesterol causes both repression of genes controlling cholesterol biosynthesis and cellular uptake and… Expand
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