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Cholesterol 7-alpha-Monooxygenase

Known as: Cytochrome P-450 CYP7, Cholesterol 7-alpha-Hydroxylase, Cholesterol-7-Hydroxylase 
A membrane-bound cytochrome P450 enzyme that catalyzes the 7-alpha-hydroxylation of CHOLESTEROL in the presence of molecular oxygen and NADPH… 
National Institutes of Health

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Related topics

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7alpha hydroxylaseIn BloodProcess of secretionantagonists & inhibitors

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CYP7A1 protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
A novel bile acid-activated vitamin D receptor signaling in human hepatocytes.
Vitamin D receptor (VDR) is activated by natural ligands, 1alpha, 25-dihydroxy-vitamin D(3) [1alpha,25(OH)(2)-D(3)] and… 
Highly Cited
2008
Highly Cited
2008
Absence of HDL cholesteryl ester uptake in mice via SR-BI impairs an adequate adrenal glucocorticoid-mediated stress response to fasting Published, JLR Papers in Press, January 19, 2008.
Receptor-mediated cholesterol uptake has been suggested to play a role in maintaining the adrenal intracellular free cholesterol… 
Highly Cited
2006
Highly Cited
2006
Liver X Receptor (LXR)-β Regulation in LXRα-Deficient Mice: Implications for Therapeutic Targeting
The nuclear receptors liver X receptor (LXR) LXRα and LXRβ are differentially expressed ligand-activated transcription factors… 
Highly Cited
2003
Highly Cited
2003
Guggulsterone antagonizes farnesoid X receptor induction of bile salt export pump but activates pregnane X receptor to inhibit cholesterol 7alpha-hydroxylase gene.
Review
2002
Review
2002
Steroid and sterol 7-hydroxylation: ancient pathways
Highly Cited
2002
Highly Cited
2002
Requirement for thyroid hormone receptor beta in T3 regulation of cholesterol metabolism in mice.
T3 potently influences cholesterol metabolism through the nuclear thyroid hormone receptor beta (TRbeta), the most abundant TR… 
Review
2002
Review
2002
25R,26-Hydroxycholesterol revisited: synthesis, metabolism, and biologic roles.
The CYP27 gene is expressed in arterial endothelium, macrophages, and other tissues. The gene product generates sterol… 
Highly Cited
1999
Highly Cited
1999
Chinese green tea lowers cholesterol level through an increase in fecal lipid excretion.
Highly Cited
1979
Highly Cited
1979
Hypolipidemic effects in dogs of ML-236B, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase.
Highly Cited
1976
Highly Cited
1976
Effect of chenodeoxycholic acid and phenobarbital on the rate-limiting enzymes of hepatic cholesterol and bile acid synthesis in patients with gallstones.
The effects of chenodeoxycholic (CDC), 750 mg. per day, phenobarbital (PB), 90 or 180 mg., combined (CDC + PB), and placebo on… 
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