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Cholesterol 7-alpha-Monooxygenase

Known as: Cytochrome P-450 CYP7, Cholesterol 7-alpha-Hydroxylase, Cholesterol-7-Hydroxylase 
A membrane-bound cytochrome P450 enzyme that catalyzes the 7-alpha-hydroxylation of CHOLESTEROL in the presence of molecular oxygen and NADPH… 
National Institutes of Health

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7alpha hydroxylaseIn BloodProcess of secretionantagonists & inhibitors

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CYP7A1 protein, human

Papers overview

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Highly Cited
2006
Highly Cited
2006
Hypocholesterolemic action of pre-germinated brown rice in hepatoma-bearing rats.
Highly Cited
2005
Highly Cited
2005
Synthetic LXR agonists increase LDL in CETP species Published, JLR Papers in Press, July 16, 2005. DOI 10.1194/jlr.M500116-JLR200
Liver X receptor (LXR) nuclear receptors regulate the expression of genes involved in whole body cholesterol trafficking… 
Highly Cited
2002
Highly Cited
2002
Regulation of hepatic low-density lipoprotein receptor, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and cholesterol 7alpha-hydroxylase mRNAs in human liver.
To characterize the coordinate regulation of cholesterol metabolism in human liver, we simultaneously quantified mRNA levels of… 
Highly Cited
2002
Highly Cited
2002
Dietary Cholesterol Fails to Stimulate the Human Cholesterol 7α-Hydroxylase Gene (CYP7A1) in Transgenic Mice* 210
Dietary cholesterol has been shown to have a stimulatory effect on the murine cholesterol 7α-hydroxylase gene (Cyp7a1), but its… 
Highly Cited
2000
Highly Cited
2000
Down-regulation of intestinal scavenger receptor class B, type I (SR-BI) expression in rodents under conditions of deficient bile delivery to the intestine.
Scavenger receptor class B, type I (SR-BI) is expressed in the intestines of rodents and has been suggested to be involved in the… 
Highly Cited
1999
Highly Cited
1999
Phenotypic characterization of Lith genes that determine susceptibility to cholesterol cholelithiasis in inbred mice: integrated activities of hepatic lipid regulatory enzymes.
There is no consensus whether hepatic lipid regulatory enzymes play primary or secondary roles in cholesterol cholelithiasis. We… 
Highly Cited
1997
Highly Cited
1997
Hypocholesterolemic action of beta-cyclodextrin and its effects on cholesterol metabolism in pigs fed a cholesterol-enriched diet.
To examine the effects of beta-cyclodextrin (BCD), a non-absorbable carbohydrate, on lipid metabolism, growing pigs were fed a 0… 
Highly Cited
1994
Highly Cited
1994
Effect of squalene synthase inhibition on the expression of hepatic cholesterol biosynthetic enzymes, LDL receptor, and cholesterol 7 alpha hydroxylase.
Squalene synthase catalyzes the committed step in the biosynthesis of sterols. Treating rats with zaragozic acid A, a potent… 
Highly Cited
1981
Highly Cited
1981
Reversible activation-inactivation of cholesterol 7alpha-hydroxylase possibly due to phosphorylation-dephosphorylation.
Highly Cited
1978
Highly Cited
1978
The submicrosomal localization of 3-hydroxy-3-methylglutaryl-coenzyme-A reductase, cholesterol 7alpha-hydroxylase and cholesterol in rat liver.
In order to determine the submicrosomal distribution of cholesterol 7α-hydroxylase, 3-hydroxy-3-methylglutaryl-coenzyme-A… 
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