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Chlormethiazole

Known as: CLOMETHIAZOLE, Chlormethiazole [Chemical/Ingredient], Thiazole, 5-(2-chloroethyl)-4-methyl- 
A sedative and anticonvulsant often used in the treatment of alcohol withdrawal. Chlormethiazole has also been proposed as a neuroprotective agent… 
National Institutes of Health

Related topics

Related topics

15 relations

Narrower (3)

5-acetyl-4-methylthiazoleDistraneurinclomethiazole edisylate

Broader (5)

AnticonvulsantsAzolesGABA ModulatorsHypnotics and Sedatives
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2002
2002
Preconditioned resistance to oxygen–glucose deprivation-induced cortical neuronal death: alterations in vesicular GABA and glutamate release
2002
2002
Clinical trial of the neuroprotectant clomethiazole in coronary artery bypass graft surgery: a randomized controlled trial.
BACKGROUND The neuroprotective property of clomethiazole has been demonstrated in several animal models of global and focal brain… 
2000
2000
On the regulation of ischaemia‐induced glutamate efflux from rat cortex by GABA; in vitro studies with GABA, clomethiazole and pentobarbitone
Prisms of adult rat cortex were maintained in vitro in either aerobic conditions (control) or conditions simulating an acute… 
Highly Cited
1999
Highly Cited
1999
Cubic phases for studies of drug partition into lipid bilayers.
Highly Cited
1995
Highly Cited
1995
The effect of chlormethiazole on neuronal damage in a model of transient focal ischaemia
1 The effect of chlormethiazole has been studied in a transient middle cerebral artery (MCA) occlusion model of cerebral… 
Highly Cited
1995
Highly Cited
1995
The protective action of chlormethiazole against ischaemia‐induced neurodegeneration in gerbils when infused at doses having little sedative or anticonvulsant activity
1 The effect of chlormethiazole administration on delayed neuronal death in gerbil hippocampus following transient global… 
1987
1987
Harman induces preference for ethanol in rats: Is the effect specific for ethanol?
Highly Cited
1982
Highly Cited
1982
Interactions between drugs and intravenous delivery systems.
The loss of 45 drugs from intravenous solutions during simulated infusions through plastic infusion sets; factors affecting such… 
1981
1981
Anticonvulsant Therapy. Pharmacological Basis and Practice. Second edition
Highly Cited
1980
Highly Cited
1980
Improved hypnotic treatment using chlormethiazole and temazepam.
The effects of a single 384 mg oral dose of chlormethiazole were compared with those of 20 mg of temazepam and placebo in healthy… 
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