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Chlormethiazole

Known as: CLOMETHIAZOLE, Chlormethiazole [Chemical/Ingredient], Thiazole, 5-(2-chloroethyl)-4-methyl- 
A sedative and anticonvulsant often used in the treatment of alcohol withdrawal. Chlormethiazole has also been proposed as a neuroprotective agent… 
National Institutes of Health

Related topics

Related topics

15 relations

Narrower (3)

5-acetyl-4-methylthiazoleDistraneurinclomethiazole edisylate

Broader (5)

AnticonvulsantsAzolesGABA ModulatorsHypnotics and Sedatives
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
CYP2E1 potentiates binge alcohol-induced gut leakiness, steatohepatitis, and apoptosis.
Highly Cited
2008
Highly Cited
2008
Cytochrome P450 2E1 contributes to ethanol‐induced fatty liver in mice
Cytochrome P450 2E1 (CYP2E1) is suggested to play a role in alcoholic liver disease, which includes alcoholic fatty liver… 
Highly Cited
2007
Highly Cited
2007
A simple and reliable procedure for the determination of psychoactive drugs in oral fluid by gas chromatography-mass spectrometry.
Highly Cited
2002
Highly Cited
2002
Clomethiazole Acute Stroke Study in Ischemic Stroke (CLASS-I): Final Results
Background and Purpose— A previous trial (the Clomethiazole Acute Stroke Study) generated the hypothesis that clomethiazole is… 
Highly Cited
2001
Highly Cited
2001
A study of the mechanisms involved in the neurotoxic action of 3,4‐methylenedioxymethamphetamine (MDMA, ‘ecstasy’) on dopamine neurones in mouse brain
Administration of 3,4‐methylenedioxymethamphetamine (MDMA, ‘ecstasy’) to mice produces acute hyperthermia and long‐term… 
Review
2000
Review
2000
GABA potentiation: a logical pharmacological approach for the treatment of acute ischaemic stroke
Highly Cited
2000
Highly Cited
2000
Use of headspace solid-phase microextraction (HS-SPME) in hair analysis for organic compounds.
Highly Cited
1999
Highly Cited
1999
Ethyl glucuronide--a marker of alcohol consumption and a relapse marker with clinical and forensic implications.
Ethyl glucuronide (EtG) is a non-volatile, water-soluble, direct metabolite of ethanol that can be detected in body fluids and… 
Highly Cited
1999
Highly Cited
1999
Clomethiazole acute stroke study (CLASS): results of a randomized, controlled trial of clomethiazole versus placebo in 1360 acute stroke patients.
BACKGROUND AND PURPOSE The efficacy and safety of the neuroprotective drug clomethiazole was tested in a double blind placebo… 
Highly Cited
1997
Highly Cited
1997
A new rating scale for the assessment of the alcohol-withdrawal syndrome (AWS scale).
A new rating scale for the quantitative assessment of the alcohol-withdrawal syndrome (AWS) was developed from the CIWA-A scale… 
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