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Chimerism

The occurrence in an individual of two or more cell populations of different chromosomal constitutions, derived from different individuals. This… 
National Institutes of Health

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Chimera organismMicrochimerismMosaicismaspects of radiation effects

Papers overview

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Review
2003
Review
2003
Quantitative analysis of chimerism after allogeneic stem cell transplantation by PCR amplification of microsatellite markers and capillary electrophoresis with fluorescence detection: the Tuebingen…
Quantitative analysis of chimerism after allogeneic stem cell transplantation by PCR amplification of microsatellite markers and… 
Highly Cited
2000
Highly Cited
2000
Stable mixed chimerism and tolerance using a nonmyeloablative preparative regimen in a large-animal model.
Bone marrow transplantation (BMT) has considerable potential for the treatment of malignancies, hemoglobinopathies, and… 
Highly Cited
1999
Highly Cited
1999
Anti-CD154 or CTLA4Ig obviates the need for thymic irradiation in a non-myeloablative conditioning regimen for the induction of mixed hematopoietic chimerism and tolerance.
BACKGROUND Thymic irradiation (TI) or repeated administration of T cell-depleting monoclonal antibodies (TCD mAbs) is required in… 
Highly Cited
1997
Highly Cited
1997
Modifications of the conditioning regimen for achieving mixed chimerism and donor-specific tolerance in cynomolgus monkeys.
BACKGROUND We demonstrated previously that a nonmyeloablative preparative regimen can induce mixed chimerism and allograft… 
Review
1995
Review
1995
The human immune system in hu-PBL-SCID mice.
Highly Cited
1994
Highly Cited
1994
Minimal residual disease is more common in patients who have mixed T-cell chimerism after bone marrow transplantation for chronic myelogenous leukemia.
Determining both lymphoid chimerism and the presence of minimal residual disease after allogeneic bone marrow transplantation… 
Highly Cited
1994
Highly Cited
1994
Role of intrathymic clonal deletion and peripheral anergy in transplantation tolerance induced by bone marrow transplantation in mice conditioned with a nonmyeloablative regimen.
We have investigated the mechanism of tolerance induced by allogeneic bone marrow transplantation (BMT) in mice conditioned with… 
Highly Cited
1992
Highly Cited
1992
Mixed allogeneic chimeras prepared by a non-myeloablative regimen: requirement for chimerism to maintain tolerance.
We have recently described a non-myeloablative conditioning regimen permitting engraftment of allogeneic bone marrow in mice… 
Highly Cited
1987
Highly Cited
1987
Mixed hematopoietic chimerism following bone marrow transplantation for hematologic malignancies.
Twenty-nine of 172 patients (17%) who received an allogeneic bone marrow transplant (BMT) from histocompatible sibling donors for… 
Highly Cited
1987
Highly Cited
1987
USE OF DNA RESTRICTION FRAGMENT LENGTH POLYMORPHISMS TO DOCUMENT MARROW ENGRAFTMENT AND MIXED HEMATOPOIETIC CHIMERISM FOLLOWING BONE MARROW TRANSPLANTATION
We have studied the feasibility of using DNA restriction fragment-length polymorphisms (RFLP) to study marrow engraftment in 27… 
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