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Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells.
It is shown that DAB(389)IL-2 is capable of selectively eliminating CD25-expressing Tregs from the PBMCs of cancer patients without inducing toxicity on other cellular subsets with intermediate or low expression of CD25.
Risk factors for acute GVHD and survival after hematopoietic cell transplantation.
Conditioning intensity, TBI and graft source have a combined effect on risk of AGVHD that must be considered in deciding on a treatment strategy for individual patients.
Pathophysiologic mechanisms of acute graft-vs.-host disease.
Inhibition of aldehyde dehydrogenase and retinoid signaling induces the expansion of human hematopoietic stem cells.
It is demonstrated that inhibition of ALDH with diethylaminobenzaldehyde (DEAB) delayed the differentiation of human HSCs that otherwise occurred in response to cytokines, suggesting that the ability of AL DH to generate retinoic acids is important in determining HSC fate.
Endothelial progenitor cell infusion induces hematopoietic stem cell reconstitution in vivo.
It is demonstrated that allogeneic EPC infusions can augment hematopoiesis and suggest a relationship between BM microvascular recovery and he matopoietic reconstitution in vivo.
Radiation Injury After a Nuclear Detonation: Medical Consequences and the Need for Scarce Resources Allocation
The pertinent literature on radiation injuries from human exposures and animal models is reviewed to provide a foundation for the triage and management approaches outlined in this special issue of Disaster Med Public Health Preparedness.
Granulocyte colony-stimulating factor "mobilized" peripheral blood progenitor cells accelerate granulocyte and platelet recovery after high-dose chemotherapy.
Hematopoietic growth factors used to accelerate engraftment after bone marrow transplantation and to "mobilize" peripheral blood progenitor cells (PBPC) resulted in a significantly accelerated time to recovery of granulocytes and a statistically significant difference in total costs.