Chemical Probe

Known as: Probe 
A small molecule that reacts with a known target in a predictable way, thereby showing location, identification, physiological state, etc.
National Institutes of Health

Papers overview

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2016
2016
Acetylation of histone lysine residues is one of the most well-studied post-translational modifications of chromatin, selectively… (More)
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Highly Cited
2015
Highly Cited
2015
publication may be reproduced, stored in a retrieval system, or transmitted in any form (electronic or otherwise) without prior… (More)
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Highly Cited
2013
Highly Cited
2013
Fully profiled chemical probes are essential to support the unbiased interpretation of biological experiments necessary for… (More)
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Highly Cited
2013
Highly Cited
2013
EZH2 or EZH1 is the catalytic subunit of the polycomb repressive complex 2 that catalyzes methylation of histone H3 lysine 27… (More)
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Highly Cited
2013
Highly Cited
2013
Among epigenetic "writers", "readers", and "erasers", the lysine methyltransferases G9a and GLP, which catalyze mono- and… (More)
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2013
2013
We describe the discovery of UNC1215, a potent and selective chemical probe for the methyllysine (Kme) reading function of… (More)
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2010
2010
The identification of nonporphyrin ligands for the orphan nuclear receptor Rev-erbα will enable studies of its role as a heme… (More)
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Highly Cited
2009
Highly Cited
2009
Research into the biological role of the Ca(2+)-releasing second messenger NAADP (nicotinic acid adenine dinucleotide phosphate… (More)
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Highly Cited
2007
Highly Cited
2007
S3I-201 (NSC 74859) is a chemical probe inhibitor of Stat3 activity, which was identified from the National Cancer Institute… (More)
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2001
2001
A novel chemisorption method was employed for the dissociative adsorption of methanol to surface methoxy intermediates in order… (More)
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