Chelating Activity

Known as: Chelating, Chelation, chelations 
Chelating Activity involves non-covalent, often coordinated, bonding between a metal and a biological molecule or complex where the biological… (More)
National Institutes of Health

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Chelating Activity [MoA]Chelating AgentsMT1G geneMT1G wt Allele
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Papers overview

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Highly Cited
2002
Highly Cited
2002
Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships.
Flavonoids are a class of secondary plant phenolics with significant antioxidant and chelating properties. In the human diet… (More)
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Highly Cited
2001
Highly Cited
2001
C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation
HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. Recent studies have defined… (More)
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Highly Cited
2001
Highly Cited
2001
Chelating activity of advanced glycation end-product inhibitors.
The advanced glycation end-product (AGE) hypothesis proposes that accelerated chemical modification of proteins by glucose during… (More)
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Highly Cited
2001
Highly Cited
2001
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.
Hypoxia-inducible factor (HIF) is a transcriptional complex that plays a central role in the regulation of gene expression by… (More)
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Highly Cited
2000
Highly Cited
2000
Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I.
We report here a new mitochondrial regulation occurring only in intact cells. We have investigated the effects of… (More)
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Highly Cited
1999
Highly Cited
1999
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
Hypoxia-inducible factor-1 (HIF-1) has a key role in cellular responses to hypoxia, including the regulation of genes involved in… (More)
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Review
1997
Review
1997
Iron-chelating therapy and the treatment of thalassemia.
Iron-chelating therapy with deferoxamine in patients with thalassemia major has dramatically altered the prognosis of this… (More)
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Highly Cited
1996
Highly Cited
1996
Structural aspects of antioxidant activity of flavonoids.
Flavonoids, a group of naturally occurring antioxidants and iron chelators, might be used as cardioprotective agents in… (More)
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Highly Cited
1990
Highly Cited
1990
Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.
Superoxide dismutase reduces injury in many disease processes, implicating superoxide anion radical (O2-.) as a toxic species in… (More)
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Highly Cited
1985
Highly Cited
1985
A new generation of Ca2+ indicators with greatly improved fluorescence properties.
A new family of highly fluorescent indicators has been synthesized for biochemical studies of the physiological role of cytosolic… (More)
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