Cerberus-Related Protein

Known as: Cerberus, DAN Domain Family Member 4 
Cerberus (267 aa, ~30 kDa) is encoded by the human CER1 gene. This protein may be involved in the gastrulation process.
National Institutes of Health

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BMP Receptor Signaling PathwayCER1 geneCytokine GeneCytokine Receptor Binding
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Papers overview

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Highly Cited
2005
Highly Cited
2005
Activin/Nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells.
Maintenance of pluripotency is crucial to the mammalian embryo's ability to generate the extra-embryonic and embryonic tissues… (More)
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Highly Cited
2004
Highly Cited
2004
Neural Induction in Xenopus: Requirement for Ectodermal and Endomesodermal Signals via Chordin, Noggin, β-Catenin, and Cerberus
The origin of the signals that induce the differentiation of the central nervous system (CNS) is a long-standing question in… (More)
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Review
2003
Review
2003
Secreted antagonists of the Wnt signalling pathway.
The extracellular antagonists of the Wnt signalling pathway can be divided into two broad classes. Both classes of molecule… (More)
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Highly Cited
2000
Highly Cited
2000
Endodermal Nodal-related signals and mesoderm induction in Xenopus.
In Xenopus, mesoderm induction by endoderm at the blastula stage is well documented, but the molecular nature of the endogenous… (More)
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Highly Cited
2000
Highly Cited
2000
Cerberus-like is a secreted BMP and nodal antagonist not essential for mouse development.
Mouse cerberus-like (cer-l) is a member of the Cerberus/Dan family of secreted factors. As other members of this family of… (More)
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Highly Cited
1999
Highly Cited
1999
The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals
Embryological and genetic evidence indicates that the vertebrate head is induced by a different set of signals from those that… (More)
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Highly Cited
1999
Highly Cited
1999
A mouse cerberus/Dan-related gene family.
The Xenopus cerberus gene is able to induce ectopic heads in Xenopus embryos. At the time of its identification, cerberus shared… (More)
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Highly Cited
1999
Highly Cited
1999
Antagonistic Signaling by Caronte, a Novel Cerberus-Related Gene, Establishes Left–Right Asymmetric Gene Expression
Left-right asymmetry is initiated during chick embryogenesis in small domains near Hensen's node. Subsequently, broad asymmetric… (More)
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Highly Cited
1997
Highly Cited
1997
Cerberus-like is a secreted factor with neuralizing activity expressed in the anterior primitive endoderm of the mouse gastrula
We report the isolation of mouse cerberus-like (cer-l), a gene encoding a novel secreted protein that is specifically expressed… (More)
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Highly Cited
1996
Highly Cited
1996
Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer
An abundant cDNA enriched in Spemann's organizer, cerberus, was isolated by differential screening. It encodes a secreted protein… (More)
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