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The RAS/RAF signaling pathway is an important mediator of tumor cell proliferation and angiogenesis. The novel bi-aryl urea BAY… Expand The bax gene promoter region contains four motifs with homology to consensus p53-binding sites. In cotransfection assays using… Expand The glutathione S-transferases (GST) represent a major group of detoxification enzymes. All eukaryotic species possess multiple… Expand The ability of p53 to activate transcription from specific sequences suggests that genes induced by p53 may mediate its… Expand Comparative genomic hybridization produces a map of DNA sequence copy number as a function of chromosomal location throughout the… Expand We describe here the development and implementation of a pilot-scale, in vitro, anticancer drug screen utilizing a panel of 60… Expand Deletions or mutations of the retinoblastoma gene, RB1, are common features of many tumors and tumor cell lines. Recently, the… Expand For the past 30 years strategies for the preclinical discovery and development of potential anticancer agents have been based… Expand We have previously described the application of an automated microculture tetrazolium assay (MTA) involving dimethyl sulfoxide… Expand Tumor ascites fluids from guinea pigs, hamsters, and mice contain activity that rapidly increases microvascular permeability… Expand