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Caspofungin

Known as: (4R,5S)-5-((2-Aminoethyl)amino)-N(2)-(10,12-dimethyltetradecanoyl)-4-hydroxy-L-ornithyl-L-threonyl-trans-4-hydroxy-L-prolyl-(S)-4-hydroxy-4-(P-hydroxyphenyl)-L-threonyl-threo-3-hydroxy-L-ornithyl-trans-3-hydroxy-L-proline cyclic (6-1)-peptide, (4R,5S)-5-((2-aminoethyl)amino)-n2-(10,12-dimethyltetradecanoyl)-4-hydroxy-l-ornithyl-l-threonyl-trans-4-hydroxy-l-prolyl-(s)-4-hydroxy-4-(p-hydroxyphenyl)-l-threonyl-threo-3-hydroxy-l-ornithyl-trans-3-hydroxy-l-proline cyclic (1->6) disulfide, 1-[(4R,5S)-5-[(2-Aminoethyl)amino]-N(2)-(10,12-dimethyl-1-oxotetradecyl)-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]-pneumocandin b0 
The acetate salt of an antimycotic echinocandin lipopeptide, semisynthetically derived from a fermentation product of the fungus Glarea lozoyensis… 
National Institutes of Health

Papers overview

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Review
2008
Review
2008
BACKGROUND It has been axiomatic that echinocandins (e.g., caspofungin) are ineffective against mucormycosis. However, on the… 
Highly Cited
2007
Highly Cited
2007
BACKGROUND Invasive candidiasis is an important cause of morbidity and mortality among patients with health care-associated… 
Highly Cited
2007
Highly Cited
2007
ABSTRACT The echinocandins are being used increasingly as therapy for invasive candidiasis. Prospective sentinel surveillance for… 
Review
2005
Review
2005
SUMMARY Mucormycosis is a life-threatening fungal infection that occurs in immunocompromised patients. These infections are… 
Highly Cited
2004
Highly Cited
2004
BACKGROUND Patients with persistent fever and neutropenia often receive empirical therapy with conventional or liposomal… 
Highly Cited
2004
Highly Cited
2004
BACKGROUND Invasive aspergillosis (IA) is an important cause of morbidity and mortality among immunocompromised patients… 
Review
2003
Review
2003
Highly Cited
2003
Highly Cited
2003
ABSTRACT We examined the in vitro activity of caspofungin, posaconazole, voriconazole, ravuconazole, itraconazole, and… 
Highly Cited
2002
Highly Cited
2002
BACKGROUND Caspofungin is an echinocandin agent with fungicidal activity against candida species. We performed a double-blind… 
Highly Cited
2002
Highly Cited
2002
ABSTRACT Most manifestations of candidiasis are associated with biofilm formation on biological or inanimate surfaces. Candida…