Caspofungin

Known as: (4R,5S)-5-((2-Aminoethyl)amino)-N(2)-(10,12-dimethyltetradecanoyl)-4-hydroxy-L-ornithyl-L-threonyl-trans-4-hydroxy-L-prolyl-(S)-4-hydroxy-4-(P-hydroxyphenyl)-L-threonyl-threo-3-hydroxy-L-ornithyl-trans-3-hydroxy-L-proline cyclic (6-1)-peptide, (4R,5S)-5-((2-aminoethyl)amino)-n2-(10,12-dimethyltetradecanoyl)-4-hydroxy-l-ornithyl-l-threonyl-trans-4-hydroxy-l-prolyl-(s)-4-hydroxy-4-(p-hydroxyphenyl)-l-threonyl-threo-3-hydroxy-l-ornithyl-trans-3-hydroxy-l-proline cyclic (1->6) disulfide, 1-[(4R,5S)-5-[(2-Aminoethyl)amino]-N(2)-(10,12-dimethyl-1-oxotetradecyl)-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]-pneumocandin b0 
The acetate salt of an antimycotic echinocandin lipopeptide, semisynthetically derived from a fermentation product of the fungus Glarea lozoyensis… (More)

Topic mentions per year

Topic mentions per year

1987-2017
010020019872017

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
The echinocandins are being used increasingly as therapy for invasive candidiasis. Prospective sentinel surveillance for the… (More)
  • table 1
  • table 2
  • table 3
Is this relevant?
Highly Cited
2007
Highly Cited
2007
BACKGROUND Invasive candidiasis is an important cause of morbidity and mortality among patients with health care-associated… (More)
  • table 1
  • table 2
  • table 3
  • table 4
  • table 5
Is this relevant?
2005
2005
Caspofungin is a parenteral antifungal that inhibits beta-1,3-D-glucan synthesis. Although licensed for adult use, the… (More)
Is this relevant?
Highly Cited
2004
Highly Cited
2004
BACKGROUND Patients with persistent fever and neutropenia often receive empirical therapy with conventional or liposomal… (More)
Is this relevant?
Highly Cited
2004
Highly Cited
2004
BACKGROUND Invasive aspergillosis (IA) is an important cause of morbidity and mortality among immunocompromised patients… (More)
  • table 1
  • table 2
  • table 3
  • table 4
  • table 5
Is this relevant?
2004
2004
BACKGROUND Invasive candidiasis is an increasing problem in neonatal intensive care units worldwide and is an important cause of… (More)
Is this relevant?
Highly Cited
2003
Highly Cited
2003
We examined the in vitro activity of caspofungin, posaconazole, voriconazole, ravuconazole, itraconazole, and amphotericin B… (More)
  • table 1
Is this relevant?
Highly Cited
2002
Highly Cited
2002
BACKGROUND Caspofungin is an echinocandin agent with fungicidal activity against candida species. We performed a double-blind… (More)
  • table 3
  • table 4
  • table 5
  • table 6
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Most manifestations of candidiasis are associated with biofilm formation on biological or inanimate surfaces. Candida albicans… (More)
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Caspofungin, a glucan synthesis inhibitor, is being developed as a parenteral antifungal agent. The pharmacokinetics of… (More)
Is this relevant?