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L 743,872
Known as:
L 743872
, L-743,872
, L-743872
National Institutes of Health
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Related topics
Related topics
2 relations
Broader (2)
Caspofungin
Caspofungin acetate
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1998
Highly Cited
1998
Comparison of In Vitro Activities of the New Triazole SCH56592 and the Echinocandins MK-0991 (L-743,872) and LY303366 against Opportunistic Filamentous and Dimorphic Fungi and Yeasts
A. Espinel-Ingroff
Journal of Clinical Microbiology
1998
Corpus ID: 9467636
ABSTRACT The in vitro antifungal activities of SCH56592, MK-0991, and LY303366 against 83 isolates of Acremonium strictum…
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Highly Cited
1998
Highly Cited
1998
Efficacy of MK-991 (L-743,872), a Semisynthetic Pneumocandin, in Murine Models ofPneumocystis carinii
M. Powles
,
P. Liberator
,
+8 authors
D. Schmatz
Antimicrobial Agents and Chemotherapy
1998
Corpus ID: 37303072
ABSTRACT In addition to its potent efficacy in animal models against Candida sp., Aspergillus fumigatus, and Histoplasma…
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Highly Cited
1998
Highly Cited
1998
Activity of MK-0991 (L-743,872), a new echinocandin, compared with those of LY303366 and four other antifungal agents tested against blood stream isolates of Candida spp.
F. Marco
,
M. Pfaller
,
S. Messer
,
R. Jones
Diagnostic microbiology and infectious disease
1998
Corpus ID: 46392442
MK-0991 (formerly L-743,872) is a water soluble semisynthetic echinocandin that possess potent, broad-spectrum antifungal…
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Highly Cited
1997
Highly Cited
1997
In vitro preclinical evaluation studies with the echinocandin antifungal MK-0991 (L-743,872).
K. Bartizal
,
C. Gill
,
+8 authors
J. Balkovec
Antimicrobial agents and chemotherapy
1997
Corpus ID: 37595998
The echinocandin MK-0991, formerly L-743,872, is a water-soluble lipopeptide that has been demonstrated in preclinical studies to…
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Highly Cited
1997
Highly Cited
1997
Preliminary animal pharmacokinetics of the parenteral antifungal agent MK-0991 (L-743,872).
R. Hajdu
,
R. Thompson
,
+4 authors
H. Kropp
Antimicrobial agents and chemotherapy
1997
Corpus ID: 25529825
MK-0991 (L-743,872) is a potent antifungal agent featuring long half-life pharmacokinetics. The pharmacokinetics of MK-0991…
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Highly Cited
1997
Highly Cited
1997
Evaluation of the echinocandin antifungal MK-0991 (L-743,872): efficacies in mouse models of disseminated aspergillosis, candidiasis, and cryptococcosis.
G. Abruzzo
,
A. Flattery
,
+9 authors
K. Bartizal
Antimicrobial agents and chemotherapy
1997
Corpus ID: 2784117
The in vivo activity of the Merck antifungal echinocandin drug candidate MK-0991 (L-743,872) was evaluated in mouse models of…
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Highly Cited
1997
Highly Cited
1997
In vitro activity of a new pneumocandin antifungal, L-743,872, against azole-susceptible and -resistant Candida species.
J. Vázquez
,
M. Lynch
,
D. Boikov
,
J. Sobel
Antimicrobial agents and chemotherapy
1997
Corpus ID: 22685124
The in vitro activity of a new pneumocandin, L-743,872, was evaluated with 108 strains of Candida and compared with the…
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Highly Cited
1997
Highly Cited
1997
Pneumocandin L-743,872 enhances the activities of amphotericin B and fluconazole against Cryptococcus neoformans in vitro.
S. Franzot
,
A. Casadevall
Antimicrobial agents and chemotherapy
1997
Corpus ID: 21592504
Cryptococcus neoformans infections in patients with AIDS are often incurable, despite aggressive antifungal therapy. Combination…
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Highly Cited
1997
Highly Cited
1997
Treatment of murine Candida krusei or Candida glabrata infection with L-743,872.
J. Graybill
,
Rafael Castillo Bocanegra
,
M. Luther
,
A. Fothergill
,
M. Rinaldi
Antimicrobial agents and chemotherapy
1997
Corpus ID: 33650965
L-743,872 is a broad-spectrum pneumocandin antifungal drug developed by Merck Research Co., and in the present work it was…
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Highly Cited
1997
Highly Cited
1997
In vitro growth-inhibitory activity of pneumocandins L-733,560 and L-743,872 against putatively amphotericin B- and fluconazole-resistant Candida isolates: influence of assay conditions.
P. W. Nelson
,
M. Lozano-Chiu
,
J. Rex
Journal of medical and veterinary mycology : bi…
1997
Corpus ID: 45333579
L-733,560 and L-743,872 are water-soluble pneumocandins with potent antifungal activity. By beginning with the NCCLS M27-T method…
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