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Carfecillin

Known as: 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-((1,3-dioxo-3-phenoxy-2-phenylpropyl)amino)-3,3-dimethyl-7-oxo-, (2S-(2alpha,5alpha,6beta))-, Carfecillin [Chemical/Ingredient], Carphecillin 
The phenyl ester of CARBENICILLIN that, upon oral administration, is broken down in the intestinal mucosa to the active antibacterial. It is used for… 
National Institutes of Health

Related topics

Related topics

12 relations

Broader (2)

Anti-Bacterial AgentsAnti-Infective Agents, Urinary

Narrower (3)

BRL-3475Carbenicillin Phenyl SodiumUticillin
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1984
1984
Light scattering studies on micelle formation by some penicillins in aqueous solution
The aggregation of a number of penicillins, both in water and in electrolyte solution, has been examined by total intensity light… 
1984
1984
Clinical pharmacokinetics of carbenicillin, carfecillin, ticarcillin and BL-P 1654 in dairy cows.
The minimal inhibitory concentrations (MIC) of carbenicillin, ticarcillin and BL-P 1654 for gram-negative udder pathogens were… 
1981
1981
Short-term antibiotic prophylaxis and prostatectomy.
Two hundred patients undergoing prostatic surgery at 2 hospitals were randomly allocated into 4 equal groups. The groups were a… 
1981
1981
Comparative Efficacy of Single- and Eight-Day Treatment of Urinary Tract Infections with Carfecillin (Uticillin)
Introduction The wisdom of treating uncomplicated urinary tract infections with conventional 5-10 day courses of antibacterial… 
1980
1980
The availability of carfecillin and its phenol moiety in rat and dog.
1. Studies have shown that hydrolysis of carfecillin to carbenicillin and phenol in vitro occurs in blood, liver and gut tissues… 
1980
1980
The metabolism of carfecillin in rat, dog and man.
1. The absorption of the phenol moiety of [phenol-14C]carfecillin following oral administration to rat, dog and man was extensive… 
1977
1977
Pharmacokinetics of carfecillin and carindacillin.
The pharmacokinetics of carfecillin and carindacillin was compared in 10 volunteers. The pharmacokinetic parameters of both… 
1977
1977
Carfecillin: antibacterial activity in vitro and in vivo.
Carfecillin, the alpha-phenyl ester of carbenicillin, hydrolyses rapidly in the presence of serum or body tissues to liberate… 
1975
1975
Volunteer and clinical studies with carfecillin: a new orally administered ester of carbenicillin.
Blood and urine levels of carbenicillin were measured in 10 healthy volunteers and four patients with renal failure after single… 
1975
1975
Preparation, hydrolysis, and oral absorption of alpha-carboxy esters of carbenicillin.
Twelve alpha-carboxy esters of carbenicillin, a parenteral broad spectrum semisynthetic penicillin, were synthesized and examined… 
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