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BRL 17421 , a Novel f ,-Lactam Antibiotic , Highly Resistant to , 8-Lactamases , Giving High and Prolonged Serum Levels in Humans
The compound exhibits exceptional stability to a wide range of bacterial /8-lactamases and is active against the majority of Enterobacteriaceae, including strains highly resistant to many of the penicillins and cephalosporins currently available.
In vitro antibacterial properties of BRL 36650, a novel 6 alpha-substituted penicillin
BRL 36650 is a new type of penicillin in which a formamido group has been introduced into the 6 alpha-position of the nucleus. The compound is highly active against aerobic gram-negative bacteria and
BRL 17421, a novel beta-lactam antibiotic, highly resistant to beta-lactamases, giving high and prolonged serum levels in humans
The compound was well tolerated after intramuscular and intravenous administration in volunteers, with no adverse side effects, and was markedly less active against Pseudomonas aeruginosa and Bacteroides fragilis than against the Enterobacteriaceae.
Comparative activities of ampicillin, epicillin and amoxycillin in vitro and in vivo.
Epicillin was similar to or slightly less active than ampicillin against experimental mouse infections, and against the majority of infections both compounds were significantly less effective than amoxycillin by the oral and subcutaneous routes of administration.
Effect of Zinc and Microbial Inoculation on Soil Enzyme Activities for Maize (Zea mays L.) in Black Soil
Maize (Zea mays L.) is one of the world’s most widely grown cereals, having great significance as human food, animal feed and raw material source for large number of industrial products (Gajendra et
Conventional laboratory agar media provide an iron-limited environment for bacterial growth
High-molecular-weight proteins similar to those produced by these strains in an iron-limited chemically defined medium were detected in cells grown on the surface of various agar media, but these proteins were not produced or were only poorly expressed by the corresponding broth cultures or by cells grown an agar supplemented with iron.
Synergy Between Ticarcillin and Tobramycin Against Pseudomonas aeruginosa and Enterobacteriaceae In Vitro and In Vivo
The results of these in vitro and in vivo studies suggest that combined therapy with ticarcillin and tobramycin may be warranted in the treatment of serious infections due to P. aeruginosa and Enterobacteriaceae.
Properties of MM 13902 and other carbapenem antibiotics in vitro and in vivo.
Pharmacokinetic studies with MM 13902 in various animal species showed that the compound was rapidly eliminated from the blood and gave only low urinary recoveries, and the nephrotoxicity reported for thienamycin/MK 0787 in the rabbit was not seen with the olivanic acidsMM 13902, MM 17880, MM 22382 and MM 22383 when tested under the same conditions.
Comparative antibacterial activity of azlocillin, mezlocillin, carbenicillin and ticarcillin and relative stability to beta-lactamases of pseudomonas aeruginosa and klebsiella aerogenes
It seems probable that the inoculum effect seen with azlocillin and mezlocillin in antibacterial tests withK.