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Cap-Binding Protein Complex

Known as: Cap Binding Protein Complex 
A heterodimeric protein complex of RNA cap-binding proteins which binds with high affinity to the 5' MRNA CAP STRUCTURE.
National Institutes of Health

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Broader (1)

RNA Cap-Binding Proteins

Papers overview

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Highly Cited
2003
Highly Cited
2003
Enterovirus 71 contains a type I IRES element that functions when eukaryotic initiation factor eIF4G is cleaved.
Highly Cited
1997
Highly Cited
1997
A new translational regulator with homology to eukaryotic translation initiation factor 4G
Translation initiation in eukaryotes is facilitated by the cap structure, m7GpppN (where N is any nucleotide). Eukaryotic… 
Highly Cited
1993
Highly Cited
1993
TIF4631 and TIF4632: two yeast genes encoding the high-molecular-weight subunits of the cap-binding protein complex (eukaryotic initiation factor 4F) contain an RNA recognition motif-like sequence…
The 5' ends of eukaryotic mRNAs are blocked by a cap structure, m7GpppX (where X is any nucleotide). The interaction of the cap… 
Highly Cited
1988
Highly Cited
1988
Relationship of p220 cleavage during picornavirus infection to 2A proteinase sequencing
Infection of HeLa cells by poliovirus results in an abrupt inhibition of host cell protein synthesis. It is thought that the… 
Highly Cited
1987
Highly Cited
1987
Regulated phosphorylation and low abundance of HeLa cell initiation factor eIF-4F suggest a role in translational control. Heat shock effects on eIF-4F.
Highly Cited
1985
Highly Cited
1985
Isolation and structural characterization of cap-binding proteins from poliovirus-infected HeLa cells
In poliovirus-infected HeLa cells, poliovirus RNA is translated at times when cellular mRNA translation is strongly inhibited. It… 
1985
1985
Poliovirus protease does not mediate cleavage of the 220,000-Da component of the cap binding protein complex.
Poliovirus infection of HeLa cells results in a rapid shutoff of host protein synthesis but does not inhibit the translation of… 
Highly Cited
1984
Highly Cited
1984
Functional characterization of eukaryotic mRNA cap binding protein complex: effects on translation of capped and naturally uncapped RNAs.
We examined the effects of a eukaryotic mRNA cap binding protein (CBP) complex purified by cap analogue affinity chromatography… 
Review
1983
Review
1983
Role of mRNA competition in regulating translation: further characterization of mRNA discriminatory initiation factors.
Host and reovirus mRNAs compete with one another for translation in infected cells. Kinetic analysis has suggested that the site… 
Highly Cited
1982
Highly Cited
1982
Inhibition of HeLa cell protein synthesis following poliovirus infection correlates with the proteolysis of a 220,000-dalton polypeptide associated with eucaryotic initiation factor 3 and a cap…
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