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Calcimimetic Agents

Known as: ANTI-PARATHYROID AGENTS, Agents, Calcimimetic 
Small organic molecules that act as allosteric activators of the calcium sensing receptor (CaSR) in the PARATHYROID GLANDS and other tissues. They… 
National Institutes of Health

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In Bloodagonistsaspects of radiation effectschemical synthesis

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cinacalcet hydrochloride

Papers overview

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Highly Cited
2017
Highly Cited
2017
Effect of Etelcalcetide vs Placebo on Serum Parathyroid Hormone in Patients Receiving Hemodialysis With Secondary Hyperparathyroidism: Two Randomized Clinical Trials
Importance Secondary hyperparathyroidism contributes to extraskeletal complications in chronic kidney disease. Objective To… 
Highly Cited
2009
Highly Cited
2009
The calcimimetic R-568 retards uremia-enhanced vascular calcification and atherosclerosis in apolipoprotein E deficient (apoE-/-) mice.
Highly Cited
2009
Highly Cited
2009
Direct upregulation of parathyroid calcium-sensing receptor and vitamin D receptor by calcimimetics in uremic rats.
To investigate whether the effect of the calcimimetic AMG 641 and calcitriol on CaSR and VDR expression could be separated from… 
2009
2009
Calcium-sensing receptors modulate renin release in vivo and in vitro in the rat
Objectives Calcium-sensing receptors (CaSRs) have been localized in the juxtaglomerular apparatus where they may contribute to… 
Highly Cited
2008
Highly Cited
2008
Calcimimetic R-568 or calcitriol: equally beneficial on progression of renal damage in subtotally nephrectomized rats.
Patients with renal insufficiency develop secondary hyperparathyroidism. Monotherapy with active vitamin D or calcimimetics… 
Highly Cited
2007
Highly Cited
2007
The calcimimetic R-568 increases vitamin D receptor expression in rat parathyroid glands.
We previously demonstrated that extracellular calcium regulates vitamin D receptor (VDR) expression by parathyroid cells. Since… 
Review
2005
Review
2005
Calcimimetics and calcilytics—fooling the calcium receptor
Review
2003
Review
2003
Calcimimetic agents: review and perspectives.
BACKGROUND Recognition of the role of the extracellular calcium-sensing receptor (CaR) in mineral metabolism has greatly improved… 
Review
2000
Review
2000
Primary hyperparathyroidism: pathophysiology and impact on bone.
Primary hyperparathyroidism has been associated with bone loss, especially at cortical skeletal sites. Results from studies… 
Review
2000
Review
2000
Medical approaches to primary hyperparathyroidism.
  • G. Strewler
  • Endocrinology and metabolism clinics of North…
  • 2000
  • Corpus ID: 4728096
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