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cinacalcet hydrochloride

Known as: Hydrochloride, Cinacalcet, 1-Naphthalenemethanamine, a-methyl-N-(3-(3-(trifluoromethyl)phenyl)propyl)-,(aR)-, Hydrochloride, Alpha-methyl-N-(3-(3-(trifluoromethyl)phenyl)propyl)-1-naphthalenemethanamine, (alphaR)-hydrochloride 
The orally bioavailable hydrochloride salt of the calcimimetic cinacalcet. Cinacalcet increases the sensitivity of calcium-sensing receptors on chief… Expand
National Institutes of Health

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AMG 073

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Calcimimetic Agents
In BloodNCIt Antineoplastic Agent Terminologyagonistsanalogs & derivatives
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Papers overview

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Highly Cited
2015
Highly Cited
2015
Cinacalcet, Fibroblast Growth Factor-23, and Cardiovascular Disease in Hemodialysis: The Evaluation of Cinacalcet HCl Therapy to Lower Cardiovascular Events (EVOLVE) Trial
Background— Patients with kidney disease have disordered bone and mineral metabolism, including elevated serum concentrations of… Expand
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Highly Cited
2010
Highly Cited
2010
Effects of cinacalcet and concurrent low-dose vitamin D on FGF23 levels in ESRD.
BACKGROUND AND OBJECTIVES Fibroblast growth factor-23 (FGF23) levels are elevated in ESRD and have been associated with adverse… Expand
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Review
2009
Review
2009
Clinical Pharmacokinetic and Pharmacodynamic Profile of Cinacalcet Hydrochloride
Cinacalcet hydrochloride (cinacalcet) is a calcimimetic approved for the treatment of secondary hyperparathyroidism in patients… Expand
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Highly Cited
2008
Highly Cited
2008
Cinacalcet (KRN1493) effectively decreases the serum intact PTH level with favorable control of the serum phosphorus and calcium levels in Japanese dialysis patients.
BACKGROUND Cinacalcet hydrochloride (KRN1493) acts on the parathyroid calcium receptors to suppress parathyroid hormone (PTH… Expand
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Highly Cited
2008
Highly Cited
2008
Cinacalcet HCl and concurrent low-dose vitamin D improves treatment of secondary hyperparathyroidism in dialysis patients compared with vitamin D alone: the ACHIEVE study results.
BACKGROUND AND OBJECTIVES Patients with chronic kidney disease (CKD) receiving dialysis often develop secondary… Expand
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Highly Cited
2007
Highly Cited
2007
Cinacalcet hydrochloride reduces the serum calcium concentration in inoperable parathyroid carcinoma.
BACKGROUND Management of inoperable parathyroid carcinoma presents a challenge because until recently, effective medical therapy… Expand
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Review
2007
Review
2007
Allosteric modulation of heterodimeric G-protein-coupled receptors.
G-protein-coupled receptors (GPCRs) are, and will probably remain, the most tractable class of targets for the development of… Expand
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Highly Cited
2005
Highly Cited
2005
Cinacalcet hydrochloride maintains long-term normocalcemia in patients with primary hyperparathyroidism.
Calcimimetics increase the sensitivity of parathyroid calcium-sensing receptors to extracellular calcium, thereby reducing PTH… Expand
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Highly Cited
2005
Highly Cited
2005
Cinacalcet hydrochloride is an effective treatment for secondary hyperparathyroidism in patients with CKD not receiving dialysis.
BACKGROUND Secondary hyperparathyroidism develops early in patients with chronic kidney disease (CKD). Clinical guidelines from… Expand
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Highly Cited
2004
Highly Cited
2004
Cinacalcet for secondary hyperparathyroidism in patients receiving hemodialysis.
BACKGROUND Treatment of secondary hyperparathyroidism with vitamin D and calcium in patients receiving dialysis is often… Expand
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