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CYP3A4*18 Allele

Known as: CYP3A4*18, CYP3A4, L293P, Cytochrome P450, Family 3, Subfamily A, Polypeptide 4*18 Allele 
Human CYP3A4*18 allele is located in the vicinity of 7q21.1 and is approximately 27 kb in length. This allele, a variant form of the CYP3A4 wild-type… 
National Institutes of Health

Related topics

Related topics

14 relations
7q22.1Carcinogen MetabolismEnhanced Biochemical ActivityIron Chelation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Influence of genetic polymorphisms on the pharmacokinetics of celecoxib and its two main metabolites in healthy Chinese subjects.
2013
2013
Biological interactions of CYP2C19 genotypes with CYP3A4*18, CYP3A5*3, and MDR1-3435 in living donor liver transplantation recipients
BackgroundPolymorphisms in CYP2C19 are related to the metabolic oxidation of drugs to varying degrees. The CYP3A4*18, CYP3A5*3… 
2012
2012
Allele and genotype frequencies of CYP3A4, CYP2C19, and CYP2D6 in Han, Uighur, Hui, and Mongolian Chinese populations.
PURPOSE This study was carried out to estimate the allele and genotype frequencies of common variants in the CYP3A4, CYP2C19, and… 
2012
2012
Genetic polymorphisms of drug-metabolizing phase I enzymes CYP3A4, CYP2C9, CYP2C19 and CYP2D6 in Han, Uighur, Hui and Mongolian Chinese populations.
We randomly evaluated 672 unrelated, healthy Chinese volunteers (136 Han, 214 Uighur, 164 Hui and 158 Mongolian) to compare… 
Highly Cited
2009
Highly Cited
2009
The CYP3A4*18 Genotype in the Cytochrome P450 3A4 Gene, a Rapid Metabolizer of Sex Steroids, Is Associated With Low Bone Mineral Density
Osteoporosis is influenced by genetic factors. The interindividual variability in the activity of CYP3A, the metabolic enzyme of… 
2009
2009
Tacrolimus Concentrations in Relation to CYP3A and ABCB1 Polymorphisms Among Solid Organ Transplant Recipients in Korea
Background. Cytochrome P450 3A (CYP3A) and the drug transporter P-glycoprotein (P-gp) affect the bioavailability of tacrolimus… 
2007
2007
The CYP3A4*18 Allele, the Most Frequent Coding Variant in Asian Populations, Does Not Significantly Affect the Midazolam Disposition in Heterozygous Individuals
The objective of this study was to identify CYP3A4 variants in Koreans and to characterize their functional consequences in vitro… 
2007
2007
Genetic polymorphisms of CYP3A4: CYP3A4*18 allele is found in five healthy Malaysian subjects.
Highly Cited
2005
Highly Cited
2005
CYP3A5*3 and CYP3A4*18 single nucleotide polymorphisms in a Chinese population.
Highly Cited
2004
Highly Cited
2004
Pharmacokinetics of midazolam in CYP3A4- and CYP3A5-genotyped subjects
ObjectiveWe investigated whether differences in pharmacokinetics of midazolam, a CYP3A probe, could be demonstrated between… 
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