Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

CYP3A4*18 Allele

Known as: CYP3A4*18, CYP3A4, L293P, Cytochrome P450, Family 3, Subfamily A, Polypeptide 4*18 Allele 
Human CYP3A4*18 allele is located in the vicinity of 7q21.1 and is approximately 27 kb in length. This allele, a variant form of the CYP3A4 wild-type… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
IntroductionImatinib mesylate (IM), a selective inhibitor of the BCR-ABL tyrosine kinase, is a well-established first-line… Expand
  • table 1
  • figure 1
  • figure 2
  • table 2
  • figure 3
Is this relevant?
2015
2015
Celecoxib is a selective cyclooxygenase-2 inhibitor used extensively for the treatment of rheumatism and osteoarthritis. The aim… Expand
Is this relevant?
2012
2012
PURPOSE This study was carried out to estimate the allele and genotype frequencies of common variants in the CYP3A4, CYP2C19, and… Expand
Is this relevant?
2012
2012
We randomly evaluated 672 unrelated, healthy Chinese volunteers (136 Han, 214 Uighur, 164 Hui and 158 Mongolian) to compare… Expand
Is this relevant?
Highly Cited
2009
Highly Cited
2009
Osteoporosis is influenced by genetic factors. The interindividual variability in the activity of CYP3A, the metabolic enzyme of… Expand
Is this relevant?
2009
2009
Background. Cytochrome P450 3A (CYP3A) and the drug transporter P-glycoprotein (P-gp) affect the bioavailability of tacrolimus… Expand
Is this relevant?
2007
2007
The objective of this study was to identify CYP3A4 variants in Koreans and to characterize their functional consequences in vitro… Expand
  • table 1
  • figure 1
  • table 2
  • figure 2
  • figure 3
Is this relevant?
2007
2007
BACKGROUND Cytochrome P450 3A4 (CYP3A4) is the major cytochrome involved in metabolizing of >60% of all drugs used in humans. A… Expand
Is this relevant?
Highly Cited
2005
Highly Cited
2005
BACKGROUND Human cytochrome P450 3A evolved to catalyze the metabolism of numerous common therapy drugs and endogenous molecules… Expand
Is this relevant?
Highly Cited
2004
Highly Cited
2004
ObjectiveWe investigated whether differences in pharmacokinetics of midazolam, a CYP3A probe, could be demonstrated between… Expand
  • figure 1
Is this relevant?