Semantic Scholar uses AI to extract papers important to this topic.
IntroductionImatinib mesylate (IM), a selective inhibitor of the BCR-ABL tyrosine kinase, is a well-established first-line… Expand Celecoxib is a selective cyclooxygenase-2 inhibitor used extensively for the treatment of rheumatism and osteoarthritis. The aim… Expand PURPOSE
This study was carried out to estimate the allele and genotype frequencies of common variants in the CYP3A4, CYP2C19, and… Expand We randomly evaluated 672 unrelated, healthy Chinese volunteers (136 Han, 214 Uighur, 164 Hui and 158 Mongolian) to compare… Expand Osteoporosis is influenced by genetic factors. The interindividual variability in the activity of CYP3A, the metabolic enzyme of… Expand Background. Cytochrome P450 3A (CYP3A) and the drug transporter P-glycoprotein (P-gp) affect the bioavailability of tacrolimus… Expand The objective of this study was to identify CYP3A4 variants in Koreans and to characterize their functional consequences in vitro… Expand BACKGROUND
Cytochrome P450 3A4 (CYP3A4) is the major cytochrome involved in metabolizing of >60% of all drugs used in humans. A… Expand BACKGROUND
Human cytochrome P450 3A evolved to catalyze the metabolism of numerous common therapy drugs and endogenous molecules… Expand ObjectiveWe investigated whether differences in pharmacokinetics of midazolam, a CYP3A probe, could be demonstrated between… Expand