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CYP2C9*2 Allele

Known as: CYP2C9*2, Cytochrome P450, Family 2, Subfamily C, Polypeptide 9*2 Allele, CYP2C9, c.430C>T 
Human CYP2C9*2 allele is located within 10q24 and is approximately 33 kb in length. This allele, a variant form of the CYP2C9 wild-type allele… 
National Institutes of Health

Related topics

Related topics

12 relations
10q24Cytosine to Thymidine Transition AbnormalityDecreased Biochemical ActivityIron Chelation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
CYP2C9 allele frequency differences between populations of Mexican-Mestizo, Mexican-Tepehuano, and Spaniards
Earlier we had found that the CYP2C9*2 allelic frequency was lower in Mexican-Americans living in California than in Spaniards… 
Highly Cited
2007
Highly Cited
2007
GENETIC POLYMORPHISMS OF CYTOCHROME P450 ENZYMES 2C9 AND 2C19 IN A HEALTHY IRANIAN POPULATION
1 The genetically polymorphic cytochrome P450 enzymes 2C9 (CYP2C9) and 2C19 (CYP2C19) are involved in the metabolism and… 
Review
2005
Review
2005
CYP2C9 gene variants, drug dose, and bleeding risk in warfarin-treated patients: A HuGEnet™ systematic review and meta-analysis
Purpose: Two common variant alleles of the cytochrome CYP2C9 (CYP2C9*2 and CYP2C9*3) lead to reduced warfarin metabolism in vitro… 
Highly Cited
2005
Highly Cited
2005
CYP2C9 Haplotype Structure in European American Warfarin Patients and Association with Clinical Outcomes
Highly Cited
2004
Highly Cited
2004
Upstream and coding region CYP2C9 polymorphisms: correlation with warfarin dose and metabolism.
OBJECTIVES To assess whether CYP2C9 alleles other than CYP2C9*2 and *3 are associated with a low-warfarin dose requirement and… 
Review
2003
Review
2003
Pharmacogenetics of CYP2C9 and interindividual variability in anticoagulant response to warfarin
Pharmacogenetics of CYP2C9 and interindividual variability in anticoagulant response to warfarin 
Highly Cited
2001
Highly Cited
2001
Genetic polymorphism of cytochrome P450 2C9 in a Caucasian and a black African population.
AIMS CYP2C9 is a major enzyme in human drug metabolism and the polymorphism observed in the corresponding gene may affect the… 
Highly Cited
2001
Highly Cited
2001
Phenytoin metabolic ratio: a putative marker of CYP2C9 activity in vivo.
CYP2C9 mediates the oxidative metabolism of approximately 10% of drugs, some of which are characterized by a narrow therapeutic… 
Highly Cited
1999
Highly Cited
1999
Validation of methods for CYP2C9 genotyping: frequencies of mutant alleles in a Swedish population.
Cytochrome P450 2C9 (CYP2C9) catalysis the metabolism of important drugs such as phenytoin, S-warfarin, tolbutamide, losartan… 
Highly Cited
1996
Highly Cited
1996
Lung cancer risk in relation to the CYP2C9*1/CYP2C9*2 genetic polymorphism among African-Americans and Caucasians in Los Angeles County, California.
CYP2C9 is involved in the metabolism of warfarin and a wide array of other therapeutic agents. It also appears to play a role… 
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