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Antithrombotic therapy for VTE disease: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.
Strong recommendations apply to most patients, whereas weak recommendations are sensitive to differences among patients, including their preferences. Expand
Antithrombotic Therapy for VTE Disease: CHEST Guideline and Expert Panel Report.
Recommendations on 12 topics that were in the 9th edition of these guidelines are updated, and 3 new topics are addressed. Expand
Derivation of a simple clinical model to categorize patients probability of pulmonary embolism: increasing the models utility with the SimpliRED D-dimer.
The combination of a score < or =4.0 by the authors' simple clinical prediction rule and a negative SimpliRED D-Dimer result may safely exclude PE in a large proportion of patients with suspected PE. Expand
Value of assessment of pretest probability of deep-vein thrombosis in clinical management
Management of patients with suspected deep-vein thrombosis based on clinical probability and ultrasound of the proximal deep veins is safe and feasible and the need for serial ultrasound testing is reduced and the rate of false-negative or false-positive ultrasound studies is reduced. Expand
Systematic overview of warfarin and its drug and food interactions.
The consistency of reports of interactions with azole antibiotics, macrolides, quinolones, nonsteroidal anti-inflammatory drugs, including selective cyclooxygenase-2 inhibitors, selective serotonin reuptake inhibitors, omeprazole, lipid-lowering agents, amiodarone, and fluorouracil suggests that coadministration with warfarin should be avoided or closely monitored. Expand
Use of a Clinical Model for Safe Management of Patients with Suspected Pulmonary Embolism
- P. Wells, Jeffrey S. Ginsberg, +9 authors J. Hirsh
- Annals of Internal Medicine
- 15 December 1998
The optimal strategy for investigating patients with suspected pulmonary embolism should combine clinical assessment, ventilation-perfusion scanning, and venous ultrasonography of the lower extremities, and the group developed a useful clinical model by reviewing the literature and coming to a consensus on a scoring system. Expand
Excluding Pulmonary Embolism at the Bedside without Diagnostic Imaging: Management of Patients with Suspected Pulmonary Embolism Presenting to the Emergency Department by Using a Simple Clinical…
A diagnostic algorithm based on a simple model and a non-enzyme-linked immunosorbent d-dimer assay was used in patients presenting to emergency departments with suspected pulmonary embolism to demonstrate the safety of excluding the diagnosis of pulmonary emblism in an emergency department using diagnostic algorithms based on pretest probability and d-Dimer assay results. Expand
Risk for heparin-induced thrombocytopenia with unfractionated and low-molecular-weight heparin thromboprophylaxis: a meta-analysis.
The objective was to determine and compare the incidences of HIT in surgical and medical patients receiving thromboprophylaxis with either UFH or LMWH and to favor the use of LMWH. Expand
A comparison of three months of anticoagulation with extended anticoagulation for a first episode of idiopathic venous thromboembolism.
Patients with a first episode of idiopathic venous thromboembolism should be treated with anticoagulant agents for longer than three months, according to a prespecified interim analysis of efficacy. Expand
Evaluation of D-dimer in the diagnosis of suspected deep-vein thrombosis.
- P. Wells, David R Anderson, +7 authors M. Kovacs
- The New England journal of medicine
- 25 September 2003
Deep-vein thrombosis can be ruled out in a patient who is judged clinically unlikely to have deep-veIn thromBosis and who has a negative D-dimer test, and ultrasound testing can be safely omitted in such patients. Expand