CYBB gene

Known as: GP91-1, p91-PHOX, NADPH OXIDASE 2 
This gene plays a role in the generation of superoxide in phagocytes.
National Institutes of Health

Papers overview

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Review
2014
Review
2014
SIGNIFICANCE Reactive oxygen species (ROS) play a critical role in vascular disease. While there are many possible sources of ROS… (More)
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Highly Cited
2012
Highly Cited
2012
By exome sequencing, we found de novo SMARCB1 mutations in two of five individuals with typical Coffin-Siris syndrome (CSS), a… (More)
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Highly Cited
2011
Highly Cited
2011
Germline mutations in CYBB, the human gene encoding the gp91phox subunit of the phagocyte NADPH oxidase, impair the respiratory… (More)
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Highly Cited
2011
Highly Cited
2011
In contrast to the NADPH oxidases Nox1 and Nox2, which generate superoxide (O(2)(·-)), Nox4 produces hydrogen peroxide (H(2)O(2… (More)
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Highly Cited
2010
Highly Cited
2010
The Nox family NADPH oxidases are reactive oxygen species (ROS)-generating enzymes that are strongly implicated in atherogenesis… (More)
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Highly Cited
2007
Highly Cited
2007
NADPH-oxidases (Nox) and the related Dual oxidases (Duox) play varied biological and pathological roles via regulated generation… (More)
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Highly Cited
2006
Highly Cited
2006
To initiate adaptative cytotoxic immune responses, proteolytic peptides derived from phagocytosed antigens are presented by… (More)
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Highly Cited
2006
Highly Cited
2006
Increased levels of reactive oxygen species (ROS) contribute to many cardiovascular diseases. In neutrophils, ROS are generated… (More)
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Highly Cited
2005
Highly Cited
2005
The integral membrane protein p22phox is an indispensable component of the superoxide-generating phagocyte NADPH oxidase, whose… (More)
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Highly Cited
2004
Highly Cited
2004
Nox1 and Nox4, homologues of the leukocyte NADPH oxidase subunit Nox2 (gp91phox) mediate superoxide anion formation in various… (More)
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