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CYBB gene

Known as: GP91-1, p91-PHOX, NADPH OXIDASE 2 
This gene plays a role in the generation of superoxide in phagocytes.
National Institutes of Health

Related topics

Related topics

7 relations
Acid-Base EquilibriumAntigen ProcessingCYBB protein, humanCell Respiration

Papers overview

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Highly Cited
2015
Highly Cited
2015
Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins
LC3-associated phagocytosis (LAP) is a process wherein elements of autophagy conjugate LC3 to phagosomal membranes. We… 
Review
2014
Review
2014
NADPH oxidases in vascular pathology.
SIGNIFICANCE Reactive oxygen species (ROS) play a critical role in vascular disease. While there are many possible sources of ROS… 
Highly Cited
2011
Highly Cited
2011
The E-loop Is Involved in Hydrogen Peroxide Formation by the NADPH Oxidase Nox4*
In contrast to the NADPH oxidases Nox1 and Nox2, which generate superoxide (O2̇̄), Nox4 produces hydrogen peroxide (H2O2). We… 
Highly Cited
2011
Highly Cited
2011
Germline CYBB mutations that selectively affect macrophages in kindreds with X-linked predisposition to tuberculous mycobacterial disease
Germline mutations in CYBB, the human gene encoding the gp91phox subunit of the phagocyte NADPH oxidase, impair the respiratory… 
Highly Cited
2009
Highly Cited
2009
Mechanism Regulating Reactive Oxygen Species in Tumor-Induced Myeloid-Derived Suppressor Cells1
Myeloid-derived suppressor cells (MDSC) are a major component of the immune suppressive network described in cancer and many… 
Review
2009
Review
2009
p47phox, the phagocyte NADPH oxidase/NOX2 organizer: structure, phosphorylation and implication in diseases
Phagocytes such as neutrophils play a vital role in host defense against microbial pathogens. The anti-microbial function of… 
Highly Cited
2007
Highly Cited
2007
Molecular evolution of the reactive oxygen-generating NADPH oxidase (Nox/Duox) family of enzymes
BackgroundNADPH-oxidases (Nox) and the related Dual oxidases (Duox) play varied biological and pathological roles via regulated… 
Highly Cited
2006
Highly Cited
2006
NOX2 Controls Phagosomal pH to Regulate Antigen Processing during Crosspresentation by Dendritic Cells
Highly Cited
2004
Highly Cited
2004
Nox4 as the Major Catalytic Component of an Endothelial NAD(P)H Oxidase
Background—Recent evidence has suggested that reactive oxygen species are important signaling molecules in vascular cells and… 
Highly Cited
2004
Highly Cited
2004
Direct Interaction of the Novel Nox Proteins with p22phox Is Required for the Formation of a Functionally Active NADPH Oxidase*
Nox1 and Nox4, homologues of the leukocyte NADPH oxidase subunit Nox2 (gp91phox) mediate superoxide anion formation in various… 
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