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CXCR4 gene

Known as: NPYY3R, LIPOPOLYSACCHARIDE-ASSOCIATED PROTEIN 3, HSY3RR 
This gene is involved in the mediation of viral entry into cells and cellular migration and chemotaxis.
National Institutes of Health

Related topics

Related topics

18 relations
Acquired Immunodeficiency SyndromeApoptosisCXCR4 ReceptorsCXCR4 WHIM-Like Mutation

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CXCR4 wt Allele

Papers overview

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2013
2013
Silencing of CXCR4 Inhibits Tumor Cell Proliferation and Neural Invasion in Human Hilar Cholangiocarcinoma
Background/Aims To evaluate the expression of CXC motif chemokine receptor 4 (CXCR4) in the tissues of patients with hilar… 
Highly Cited
2008
Highly Cited
2008
Patterns of gene expression in pig adipose tissue: insulin-like growth factor system proteins, neuropeptide Y (NPY), NPY receptors, neurotrophic factors and other secreted factors.
2005
2005
Complex Determinants in Human Immunodeficiency Virus Type 1 Envelope gp120 Mediate CXCR4-Dependent Infection of Macrophages
ABSTRACT Host cell range, or tropism, combined with coreceptor usage defines viral phenotypes as macrophage tropic using CCR5 (M… 
Highly Cited
2000
Highly Cited
2000
Simian Immunodeficiency Viruses of Diverse Origin Can Use CXCR4 as a Coreceptor for Entry into Human Cells
ABSTRACT Primary simian immunodeficiency virus (SIV) isolated from sooty mangabey (SIVsm [n = 6]), stumptail (SIVstm [n = 1… 
Highly Cited
2000
Highly Cited
2000
Coreceptor Competition for Association with CD4 May Change the Susceptibility of Human Cells to Infection with T-Tropic and Macrophagetropic Isolates of Human Immunodeficiency Virus Type 1
ABSTRACT The chemokine receptors CCR5 and CXCR4 were found to function in vivo as the principal coreceptors for M-tropic and T… 
Highly Cited
1999
Highly Cited
1999
A CD4-independent interaction of human immunodeficiency virus-1 gp120 with CXCR4 induces their cointernalization, cell signaling, and T-cell chemotaxis.
The gp120 envelope glycoprotein of human immunodeficiency virus-1 (HIV-1) interacts with the CXCR4 chemokine receptor, but it is… 
Highly Cited
1998
Highly Cited
1998
CXCR4 and CCR5 on human thymocytes: biological function and role in HIV-1 infection.
Thymocyte infection with HIV-1 is associated with thymic involution and impaired thymopoiesis, particularly in pediatric patients… 
Highly Cited
1998
Highly Cited
1998
CXCR4 Is Required by a Nonprimate Lentivirus: Heterologous Expression of Feline Immunodeficiency Virus in Human, Rodent, and Feline Cells
ABSTRACT A heterologous feline immunodeficiency virus (FIV) expression system permitted high-level expression of FIV proteins and… 
1998
1998
Dissociation of the CD4 and CXCR4 Binding Properties of Human Immunodeficiency Virus Type 1 gp120 by Deletion of the First Putative Alpha-Helical Conserved Structure
ABSTRACT To evaluate conserved structures of the surface gp120 subunit (SU) of the human immunodeficiency virus type 1 (HIV-1… 
Highly Cited
1997
Highly Cited
1997
Infectious properties of human immunodeficiency virus type 1 mutants with distinct affinities for the CD4 receptor
Recent evidence suggests that primary patient isolates of T-cell-tropic human immunodeficiency virus type 1 (HIV-1 ) have lower… 
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