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Critical role for the chemokine receptor CXCR 6 in NK cell – mediated antigen-specific memory of haptens and viruses
The textbook view of adaptive immunity is that it is mediated exclusively by T cells and B cells, which rely on nonhomologous recombination of variable, diversity and joining gene segments mediated… Expand
Identification of alpha-dystroglycan as a receptor for lymphocytic choriomeningitis virus and Lassa fever virus.
A peripheral membrane protein that is interactive with lymphocytic choriomeningitis virus (LCMV) was purified from cells permissive to infection. Tryptic peptides from this protein were determined to… Expand
The three-dimensional structure of canine parvovirus and its functional implications.
The three-dimensional atomic structure of a single-stranded DNA virus has been determined. Infectious virions of canine parvovirus contain 60 protein subunits that are predominantly VP-2. The central… Expand
Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection
- Jens Wrammert, D. Koutsonanos, +27 authors Patrick C Wilson
- The Journal of Experimental Medicine
- 14 February 2011
The Rockefeller University Press $30.00 J. Exp. Med. Vol. 208 No. 1 181-193 www.jem.org/cgi/doi/10.1084/jem.20101352 181 Influenza is the seventh leading cause of death in the United States (Beigel,… Expand
Programming the magnitude and persistence of antibody responses with innate immunity
Many successful vaccines induce persistent antibody responses that can last a lifetime. The mechanisms by which they do so remain unclear, but emerging evidence indicates that they activate dendritic… Expand
Virus-Like Particle Vaccine Induces Protective Immunity against Homologous and Heterologous Strains of Influenza Virus
ABSTRACT Recurrent outbreaks of highly pathogenic avian influenza virus pose the threat of pandemic spread of lethal disease and make it a priority to develop safe and effective vaccines. Influenza… Expand
Host cell dependence of viral morphology.
- P. C. Roberts, R. Compans
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 12 May 1998
The morphology of influenza virions was found to depend on cellular determinants. Influenza viral filaments up to 30 microm in length were observed to form at high levels on surfaces of various… Expand
Influenza type A virus neuraminidase does not play a role in viral entry, replication, assembly, or budding.
We have used a neuraminidase-deficient influenza virus, NWS-Mvi, which was selected by supplying bacterial neuraminidase in the medium (C. Liu and G. M. Air, Virology 194:403-407, 1993), to define… Expand
Alpha/Beta Interferons Potentiate Virus-Induced Apoptosis through Activation of the FADD/Caspase-8 Death Signaling Pathway
- S. Balachandran, P. C. Roberts, +4 authors G. Barber
- Biology, Medicine
- Journal of Virology
- 1 February 2000
ABSTRACT Interferon (IFN) mediates its antiviral effects by inducing a number of responsive genes, including the double-stranded RNA (dsRNA)-dependent protein kinase, PKR. Here we report that… Expand
An infectious clone of the West Nile flavivirus.
- V. Yamshchikov, G. Wengler, A. Perelygin, M. Brinton, R. Compans
- Medicine, Biology
- 15 March 2001
West Nile (WN) virus is the most widespread among flaviviruses, but until recently it was not known on the American continent. We describe here design of a subgenomic replicon, as well as a… Expand