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Critical role for the chemokine receptor CXCR 6 in NK cell – mediated antigen-specific memory of haptens and viruses
The textbook view of adaptive immunity is that it is mediated exclusively by T cells and B cells, which rely on nonhomologous recombination of variable, diversity and joining gene segments mediated…
Identification of alpha-dystroglycan as a receptor for lymphocytic choriomeningitis virus and Lassa fever virus.
A peripheral membrane protein that is interactive with lymphocytic choriomeningitis virus (LCMV) was purified from cells permissive to infection and determined to be alpha-dystroglycan (alpha-DG).
The three-dimensional structure of canine parvovirus and its functional implications.
The three-dimensional atomic structure of a single-stranded DNA virus has been determined and some of the amino termini of VP-2 run to the exterior in full but not empty virions, which is consistent with the observation that someVP-2 polypeptides in full particles can be cleaved by trypsin.
Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection
- J. Wrammert, Dimitrios G. Koutsonanos, +27 authors P. Wilson
- The Journal of Experimental Medicine
- 14 February 2011
The Rockefeller University Press $30.00 J. Exp. Med. Vol. 208 No. 1 181-193 www.jem.org/cgi/doi/10.1084/jem.20101352 181 Influenza is the seventh leading cause of death in the United States (Beigel,…
Programming the magnitude and persistence of antibody responses with innate immunity
It is demonstrated that immunization of mice with synthetic nanoparticles containing antigens plus ligands that signal through TLR4 and TLR7 induces synergistic increases in antigen-specific, neutralizing antibodies compared to immunization with nanoparticles minus a single TLR ligand, and there was enhanced persistence of germinal centres and of plasma-cell responses, which persisted in the lymph nodes for >1.5 years.
Influenza type A virus neuraminidase does not play a role in viral entry, replication, assembly, or budding
It is suggested that neuraminidase is not required for influenza virus entry, replication, or assembly in cell culture or in mice.
Alpha/Beta Interferons Potentiate Virus-Induced Apoptosis through Activation of the FADD/Caspase-8 Death Signaling Pathway
- S. Balachandran, P. Roberts, +4 authors G. Barber
- Medicine, BiologyJournal of Virology
- 1 February 2000
It is reported that inducible overexpression of functional PKR in murine fibroblasts sensitized cells to apoptosis induced by influenza virus, while in contrast, cells expressing a dominant-negative variant of PKR were completely resistant.
An infectious clone of the West Nile flavivirus.
- V. Yamshchikov, G. Wengler, A. Perelygin, M. Brinton, R. Compans
- Biology, MedicineVirology
- 15 March 2001
Design of a subgenomic replicon, as well as a full-length infectious clone of the lineage II WN strain, which appeared surprisingly stable compared to other flavivirus infectious clones, was used to investigate effects of 5'- and 3'-nonrelated sequences on virus replication and infectivity of synthetic RNA.
Host cell dependence of viral morphology.
Observations indicate that the polarized cell phenotype and the integrity of the actin microfilament network are important cellular determinants of the morphology of a filamentous influenza virus.
Virus-Like Particle Vaccine Induces Protective Immunity against Homologous and Heterologous Strains of Influenza Virus
Immune sera administered intranasally were able to confer 100% protection from a lethal challenge with PR8 or WSN, which provides further evidence that anti-HA antibodies are primarily responsible for preventing infection.