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Critical role for the chemokine receptor CXCR 6 in NK cell – mediated antigen-specific memory of haptens and viruses
The textbook view of adaptive immunity is that it is mediated exclusively by T cells and B cells, which rely on nonhomologous recombination of variable, diversity and joining gene segments mediatedExpand
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Identification of alpha-dystroglycan as a receptor for lymphocytic choriomeningitis virus and Lassa fever virus.
A peripheral membrane protein that is interactive with lymphocytic choriomeningitis virus (LCMV) was purified from cells permissive to infection. Tryptic peptides from this protein were determined toExpand
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The three-dimensional structure of canine parvovirus and its functional implications.
The three-dimensional atomic structure of a single-stranded DNA virus has been determined. Infectious virions of canine parvovirus contain 60 protein subunits that are predominantly VP-2. The centralExpand
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Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection
The Rockefeller University Press $30.00 J. Exp. Med. Vol. 208 No. 1 181-193 www.jem.org/cgi/doi/10.1084/jem.20101352 181 Influenza is the seventh leading cause of death in the United States (Beigel,Expand
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Programming the magnitude and persistence of antibody responses with innate immunity
Many successful vaccines induce persistent antibody responses that can last a lifetime. The mechanisms by which they do so remain unclear, but emerging evidence indicates that they activate dendriticExpand
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Virus-Like Particle Vaccine Induces Protective Immunity against Homologous and Heterologous Strains of Influenza Virus
ABSTRACT Recurrent outbreaks of highly pathogenic avian influenza virus pose the threat of pandemic spread of lethal disease and make it a priority to develop safe and effective vaccines. InfluenzaExpand
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Host cell dependence of viral morphology.
The morphology of influenza virions was found to depend on cellular determinants. Influenza viral filaments up to 30 microm in length were observed to form at high levels on surfaces of variousExpand
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Influenza type A virus neuraminidase does not play a role in viral entry, replication, assembly, or budding.
We have used a neuraminidase-deficient influenza virus, NWS-Mvi, which was selected by supplying bacterial neuraminidase in the medium (C. Liu and G. M. Air, Virology 194:403-407, 1993), to defineExpand
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Alpha/Beta Interferons Potentiate Virus-Induced Apoptosis through Activation of the FADD/Caspase-8 Death Signaling Pathway
ABSTRACT Interferon (IFN) mediates its antiviral effects by inducing a number of responsive genes, including the double-stranded RNA (dsRNA)-dependent protein kinase, PKR. Here we report thatExpand
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An infectious clone of the West Nile flavivirus.
West Nile (WN) virus is the most widespread among flaviviruses, but until recently it was not known on the American continent. We describe here design of a subgenomic replicon, as well as aExpand
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