CX 4945

Known as: CX-4945, CX4945 
 
National Institutes of Health

Papers overview

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2015
2015
The casein kinase 2 (CK2) protein kinase is a pro-survival kinase and therapeutic target in treatment of various human cancers… (More)
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2014
2014
Chronic lymphocytic leukemia (CLL) remains a therapeutic challenge. New immuno-chemotherapeutic approaches have had a significant… (More)
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2014
2014
Alternative splicing is a nearly ubiquitous versatile process that controls gene expression and creates numerous protein isoforms… (More)
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2013
2013
BACKGROUND The epithelial-to-mesenchymal transition (EMT) is a major phenotype of cancer metastasis and invasion. As a druggable… (More)
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2013
2013
Over-expression of protein kinase CK2 is highly linked to the survival of cancer cells and the poor prognosis of patients with… (More)
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2012
2012
CK2 is a pleiotropic protein kinase, which regulates many survival pathways and plays a global anti-apoptotic function. It is… (More)
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2011
2011
In this article we describe the preclinical characterization of 5-(3-chlorophenylamino) benzo[c][2,6]naphthyridine-8-carboxylic… (More)
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2011
2011
Protein kinase CK2 (CK2), a constitutively active serine/threonine kinase, is involved in a variety of roles essential to the… (More)
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2011
2011
Herein we chronicle the discovery of CX-4945 (25n), a first-in-class, orally bioavailable ATP-competitive inhibitor of protein… (More)
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Highly Cited
2010
Highly Cited
2010
Malignant transformation and maintenance of the malignant phenotype depends on oncogenic and non-oncogenic proteins that are… (More)
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