Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

CX 4945

Known as: CX-4945, CX4945 
 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
The casein kinase 2 (CK2) protein kinase is a pro-survival kinase and therapeutic target in treatment of various human cancers… Expand
  • figure 1
  • table 1
Is this relevant?
Highly Cited
2014
Highly Cited
2014
Constitutively active casein kinase 2 (CK2) signaling is a common feature of T-cell acute lymphoblastic leukemia (T-ALL). CK2… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2014
Highly Cited
2014
Activity of the clinical-stage CK2-specific inhibitor CX-4945 against chronic lymphocytic leukemia 
  • figure 1
  • figure 2
Is this relevant?
Highly Cited
2013
Highly Cited
2013
Background The epithelial-to-mesenchymal transition (EMT) is a major phenotype of cancer metastasis and invasion. As a druggable… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2012
Highly Cited
2012
Drug combination therapies are commonly used for the treatment of cancers to increase therapeutic efficacy, reduce toxicity, and… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2012
2012
  • J. Kim, S. Kim
  • Archives of pharmacal research
  • 2012
  • Corpus ID: 207410239
Casein kinase 2 (CK2) is involved in multiple cellular processes such as proliferation, apoptosis, and cell cycle. In particular… Expand
  • figure 1
  • figure 2
Is this relevant?
Highly Cited
2011
Highly Cited
2011
Herein we chronicle the discovery of CX-4945 (25n), a first-in-class, orally bioavailable ATP-competitive inhibitor of protein… Expand
Is this relevant?
Highly Cited
2011
Highly Cited
2011
Protein kinase CK2 (CK2), a constitutively active serine/threonine kinase, is involved in a variety of roles essential to the… Expand
Is this relevant?
Highly Cited
2011
Highly Cited
2011
In this article we describe the preclinical characterization of 5-(3-chlorophenylamino) benzo[c][2,6]naphthyridine-8-carboxylic… Expand
  • figure 1
  • table 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2010
Highly Cited
2010
Malignant transformation and maintenance of the malignant phenotype depends on oncogenic and non-oncogenic proteins that are… Expand
  • figure 1
  • table 1
  • figure 2
  • table 2
  • figure 3
Is this relevant?