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CX 4945

Known as: CX-4945, CX4945 
National Institutes of Health

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Silmitasertib Sodium

Papers overview

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2018
2018
Pharmacological Inhibition of Casein Kinase 2 Enhances the Effectiveness of PI3K Inhibition in Colon Cancer Cells
Background/Aim: Serine/threonine kinase B-Raf proto-oncogene (BRAF) mutant colon cancer has a poor prognosis and there is an… 
2017
2017
CX4945 suppresses the growth of castration-resistant prostate cancer cells by reducing AR-V7 expression
PurposeThe aberrant expression of casein kinase 2 (CK2) has been reported to be involved in the tumorigenesis and progression of… 
2016
2016
CK2 blockade causes MPNST cell apoptosis and promotes degradation of β-catenin
Malignant peripheral nerve sheath tumors (MPNSTs) are soft tissue sarcomas that are a major cause of mortality of… 
2014
2014
Autophagosome-Mediated EGFR Down-Regulation Induced by the CK2 Inhibitor Enhances the Efficacy of EGFR-TKI on EGFR-Mutant Lung Cancer Cells with Resistance by T790M
Protein kinase CK2 has diverse functions promoting and maintaining cancer phenotypes. We investigated the effect of CK2… 
2014
2014
Exploring the prominent performance of CX-4945 derivatives as protein kinase CK2 inhibitors by a combined computational study.
Protein kinase CK2, also known as casein kinase II, is related to various cellular events and is a potential target for numerous… 
2014
2014
CK2α, over-expressed in human malignant pleural mesothelioma, regulates the Hedgehog signaling pathway in mesothelioma cells
BackgroundThe Hedgehog (Hh) signaling pathway has been implicated in stem cell maintenance and its activation is aberrant in… 
2013
2013
Detection of Phospho-Sites Generated by Protein Kinase CK2 in CFTR: Mechanistic Aspects of Thr1471 Phosphorylation
By mass spectrometry analysis of mouse Cystic Fibrosis Transmembrane-conductance Regulator (mCFTR) expressed in yeast we have… 
2013
2013
CK2 inhibitor CX4945 induces sequential inactivation of proteins in the signaling pathways related with cell migration and suppresses metastasis of A549 human lung cancer cells.
2012
2012
Druggability of the CK2 inhibitor CX-4945 as an anticancer drug and beyond
Casein kinase 2 (CK2) is involved in multiple cellular processes such as proliferation, apoptosis, and cell cycle. In particular… 
2010
2010
CX-4945, a Selective and Orally Bioavailable Inhibitor of Protein Kinase CK2 Inhibits PI3K/Akt, JAK-STAT and NF-κB Signaling and Induces Apoptosis In Multiple Myeloma Cells
Abstract 787 Multiple myeloma (MM) is an incurable malignancy characterized by infiltration of malignant plasma cells in the bone… 
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