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CTL-mediated Immune Response Pathway

Known as: CTL mediated immune response against target cells 
Cytotoxic T lymphocytes (CTLs), also known as killer T cells, provide a cell-mediated response to specific foreign antigens associated with cells… 
National Institutes of Health

Related topics

Related topics

19 relations
CD247 wt AlleleCD3D protein, humanCD3D wt AlleleCD3E protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Interdisciplinary Analysis of HIV-Specific CD8+ T Cell Responses against Variant Epitopes Reveals Restricted TCR Promiscuity
HIV-1–specific CTL responses play a key role in limiting viral replication. CTL responses are sensitive to viral escape mutations… 
Highly Cited
2010
Highly Cited
2010
The Exocytosis of Lytic Granules Is Impaired in Vti1b- or Vamp8-Deficient CTL Leading to a Reduced Cytotoxic Activity following Antigen-Specific Activation
The exocytosis of cytotoxic proteins stored in lytic granules of activated CTL is a key event during killing of target cells… 
Highly Cited
2002
Highly Cited
2002
The Immunodominant, Ld-Restricted T Cell Response to Hepatitis B Surface Antigen (HBsAg) Efficiently Suppresses T Cell Priming to Multiple Dd-, Kd-, and Kb-Restricted HBsAg Epitopes1
MHC-I-restricted CTL responses of H-2d (Ld+ or Ld−) and F1 H-2dxb mice to hepatitis B surface Ag (HBsAg) are primed by either DNA… 
Highly Cited
2000
Highly Cited
2000
High Frequency of Autologous Anti-Melanoma CTL Directed Against an Antigen Generated by a Point Mutation in a New Helicase Gene1
We have identified an Ag recognized by autologous CTL on the melanoma cells of a patient who enjoyed an unusually favorable… 
Highly Cited
1999
Highly Cited
1999
Modulation of Proteasomal Activity Required for the Generation of a Cytotoxic T Lymphocyte–defined Peptide Derived from the Tumor Antigen MAGE-3
We have analyzed the presentation of human histocompatability leukocyte antigen-A*0201–associated tumor peptide antigen MAGE-3271… 
Review
1998
Review
1998
Hierarchies of antigen‐specific cytotoxic T‐cell responses
Summary: Studies carried out using either mice or humans have shown that cytotoxic T‐lymphocyte (CTL) responses to many different… 
1993
1993
Abrogation of H-2-restricted CTL responses and efficient recognition of HLA-A3 molecules in DBA/2 HLA/A24 responder mice.
DBA/2 (H-2d) HLA-B7 x human beta 2-microglobulin transgenic and DBA/2 nontransgenic mice stimulated by DBA/2 HLA-A3 x human beta… 
Highly Cited
1992
Highly Cited
1992
Identification of overlapping HLA class I-restricted cytotoxic T cell epitopes in a conserved region of the human immunodeficiency virus type 1 envelope glycoprotein: definition of minimum epitopes…
Although the immunologic basis of protective immunity in human immunodeficiency virus type 1 (HIV-1) infection has not yet been… 
Highly Cited
1992
Highly Cited
1992
Detection of a vigorous HIV-1-specific cytotoxic T lymphocyte response in cerebrospinal fluid from infected persons with AIDS dementia complex.
AIDS dementia complex is a common neurologic disorder in later stages of HIV-1 infection. Because virus-specific CTL have been… 
Highly Cited
1984
Highly Cited
1984
Immunoprecipitation of cell surface structures of cloned cytotoxic T lymphocytes by clone-specific antisera.
Clones of cytotoxic T lymphocytes (CTL) differ in their specific reactivity with diverse target cell antigens. To learn about the… 
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