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CR011-vcMMAE

Known as: Antibody-Drug Conjugate CR011-vcMMAE, CR011-vcMMAE Immunotoxin 
 
National Institutes of Health

Papers overview

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2009
2009
9032 Background: GPNMB is expressed on melanoma cells and represents a potential target for ADCs. CR011-vcMMAE is a fully-human… Expand
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2009
2009
Background: Glycoprotein NMB (GPNMB), also known as osteoactivin, is expressed in 25-40% of breast cancers and is associated with… Expand
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2009
2009
9063 Background: CR011-vcMMAE, an ADC of fully-human monoclonal anti-GPNMB antibody (Ab) with monomethylauristatin E (MMAE), is… Expand
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2009
2009
1067 Background: Glycoprotein NMB (GPNMB), also known as osteoactivin, has been shown to regulate metastasis of breast cancer in… Expand
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2008
2008
GPNMB is a melanoma-associated glycoprotein that is targeted by the CR011-vcMMAE antibody-drug conjugate (ADC). Previous studies… Expand
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2008
2008
9029 Background: Glycoprotein NMB (GPNMB) is highly expressed in melanoma. CR011-vcMMAE is comprised of a human monoclonal… Expand
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Highly Cited
2007
Highly Cited
2007
PurposeTo investigate the pharmacological properties of the CR011-vcMMAE fully human antibody–drug conjugate (ADC), such as dose… Expand
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2007
2007
B47 Background: Glycoprotein NMB (GPNMB) expression on the cell surface of melanoma cells is substantially greater than most… Expand
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2007
2007
In the previous issue of Breast Cancer Research, Metz and colleagues characterize hematopoietic growth factor inducible… Expand
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Highly Cited
2006
Highly Cited
2006
PURPOSE: Advanced melanoma is a highly drug-refractory neoplasm representing a significant unmet medical need. We sought to… Expand
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