CR011-vcMMAE

Known as: Antibody-Drug Conjugate CR011-vcMMAE, CR011-vcMMAE Immunotoxin 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2006-2016
0120062016

Papers overview

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Review
2016
Review
2016
Non-metastatic melanoma glycoprotein B (Gpnmb), a type I transmembrane glycoprotein, was first cloned and described in low… (More)
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Review
2014
Review
2014
Exploiting the highly targeted nature of monoclonal antibodies to deliver selectively to tumor cells a cytotoxic payload is an… (More)
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Review
2012
Review
2012
Cancer is a complex disease with interactions between normal and neoplastic cells. Since current therapies for cancer largely… (More)
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2009
2009
9032 Background: GPNMB is expressed on melanoma cells and represents a potential target for ADCs. CR011-vcMMAE is a fully-human… (More)
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2009
2009
9063 Background: CR011-vcMMAE, an ADC of fully-human monoclonal anti-GPNMB antibody (Ab) with monomethylauristatin E (MMAE), is… (More)
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2009
2009
1067 Background: Glycoprotein NMB (GPNMB), also known as osteoactivin, has been shown to regulate metastasis of breast cancer in… (More)
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2008
2008
GPNMB is a melanoma-associated glycoprotein that is targeted by the CR011-vcMMAE antibody-drug conjugate (ADC). Previous studies… (More)
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2007
2007
To investigate the pharmacological properties of the CR011-vcMMAE fully human antibody–drug conjugate (ADC), such as dose… (More)
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Highly Cited
2006
Highly Cited
2006
PURPOSE Advanced melanoma is a highly drug-refractory neoplasm representing a significant unmet medical need. We sought to… (More)
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