glembatumumab vedotin

An antibody-drug conjugate, consisting of the fully human monoclonal antibody CR011 directed against glycoprotein NMB (GPNMB) and conjugated via a… (More)

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Topic mentions per year

2010-2018
02420102018

Papers overview

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2017
2017
Over 50 investigational monoclonal antibody (mAb) therapeutics are currently undergoing evaluation in late-stage clinical studies… (More)
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Review
2017
Review
2017
GPNMB has emerged as an immunomodulator and an important positive mediator of tumor progression and metastasis in numerous solid… (More)
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2016
2016
BACKGROUND Cure rates for children and young adults with osteosarcoma have remained stagnant over the past three decades… (More)
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2015
2015
PURPOSE Glycoprotein NMB (gpNMB), a negative prognostic marker, is overexpressed in multiple tumor types. Glembatumumab vedotin… (More)
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2014
2014
PURPOSE The antibody-drug conjugate glembatumumab vedotin links a fully human immunoglobulin G2 monoclonal antibody against the… (More)
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2014
2014
PURPOSE Glycoprotein NMB (gpNMB), a novel transmembrane protein overexpressed in 40% to 60% of breast cancers, promotes… (More)
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2014
2014
BACKGROUND Glembatumumab vedotin is an antibody-auristatin conjugate that targets cells expressing the transmembrane glycoprotein… (More)
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Review
2014
Review
2014
Exploiting the highly targeted nature of monoclonal antibodies to deliver selectively to tumor cells a cytotoxic payload is an… (More)
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2010
2010
Glembatumumab vedotin (CR-011-vc-MMAE) is a mAb-drug conjugate being developed by Celldex Therapeutics Inc for the treatment of… (More)
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2010
2010
PURPOSE Although the murine orthologue of glycoprotein nonmetastatic B (GPNMB), Osteoactivin, promotes breast cancer metastasis… (More)
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