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CP 31398

Known as: CP-31,398, CP-31398 
National Institutes of Health

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Broader (1)

Pyrimidines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
A p53-stabilizing agent, CP-31398, induces p21 expression with increased G2/M phase through the YY1 transcription factor in esophageal carcinoma defective of the p53 pathway.
Restoration of p53 functions is one of the therapeutic strategies for esophageal carcinoma which is often defective of the p53… 
2016
2016
Targeting cancer stem cells with p53 modulators
Cancer stem cells (CSC) typically over-express aldehyde dehydrogenase (ALDH). Thus, ALDHbright tumor cells represent targets for… 
2016
2016
Chemoprevention of spontaneous ovarian cancer in the domestic hen
&NA; The hen is an attractive animal model for in vivo testing of agents that thwart ovarian carcinogenesis because ovarian… 
2014
2014
p53 Protein Regulates Hsp90 ATPase Activity and Thereby Wnt Signaling by Modulating Aha1 Expression*
Background: The mechanism by which p53, a tumor suppressor gene, regulates Wnt signaling is incompletely understood. Results: p53… 
2013
2013
A compound CP-31398 suppresses excitotoxicity-induced neurodegeneration.
Highly Cited
2012
Highly Cited
2012
Autophagy induced by p53-reactivating molecules protects pancreatic cancer cells from apoptosis
TP53 mutations compromising p53 transcriptional function occur in more than 50 % of human cancers, including pancreatic… 
2012
2012
Pharmacokinetics and tissue and tumor exposure of CP-31398, a p53-stabilizing agent, in rats
PurposeCP-31398 (N′-[2-[(E)-2-(4-methoxyphenyl)ethenyl]quinazolin-4-yl]-N,N-dimethylpropane-1,3-diamine hydrochloride) is one of… 
2009
2009
Inhibition of azoxymethane-induced colorectal cancer by CP-31398, a TP53 modulator, alone or in combination with low doses of celecoxib in male F344 rats.
Tumor suppressor p53 plays a major role in colorectal cancer development. The present study explores the effects of p53… 
Highly Cited
2004
Highly Cited
2004
CP-31398 Restores DNA-binding Activity to Mutant p53 in Vitro but Does Not Affect p53 Homologs p63 and p73*
The p53 protein plays a major role in the maintenance of genome stability in mammalian cells. Mutations of p53 occur in over 50… 
2003
2003
The p53-stabilizing compound, CP-31398, does not enhance chemosensitivity in human melanoma cells.
BACKGROUND Malignant melanoma is a life-threatening disease with a poor prognosis due to its capacity for rapid metastasis and… 
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