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Tumor rejection antigens of chemically induced sarcomas of inbred mice.
TLDR
It is proposed that structurally related but distinct Mr 96,000 glycoproteins are expressed in chemically induced sarcomas and that these molecules are responsible for the individually specific immunogenicity of these tumors. Expand
Monoclonal antibody to a triggering structure expressed on rat natural killer cells and adherent lymphokine-activated killer cells
TLDR
An mAb is described that recognizes a triggering structure that is expressed on rat LGL/NK cells and A-LAK cells and is a useful tool for the study of NK cell ontogeny and function, and the development of cells with LAK activity from the NK cell compartment. Expand
Therapy of murine tumors with tumor peptide-pulsed dendritic cells: dependence on T cells, B7 costimulation, and T helper cell 1-associated cytokines
TLDR
Using the immunogenic C3 (H-2b) tumor model in B6 mice, tumor peptide-pulsed DC therapy resulted in the erradication of established d14 tumors and long-term survival in 100% of treated animals. Expand
Bone marrow-derived dendritic cells pulsed with synthetic tumour peptides elicit protective and therapeutic antitumour immunity
TLDR
Treatment of animals bearing established macroscopic tumours with tumour peptide-pulsed dendritic cells resulted in sustained tumour regression and tumour-free status in more than 80% of cases, and support the clinical use of tumour Peptide-Pulsed Dendritic Cells as components in developing effective cancer vaccines and therapies. Expand
Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse.
TLDR
The presence of p53 in tumors of no known viral etiology indicates coding by resident cellular genes; this does not exclude endogenous viruses as the source of coding sequences or the possibility that transforming viruses code directly for p53. Expand
Identification of human aldehyde dehydrogenase 1 family member A1 as a novel CD8+ T-cell-defined tumor antigen in squamous cell carcinoma of the head and neck.
TLDR
A smaller cohort of subjects with SCCHN, whose tumors express little to no ALDH1A1, and thus are deficient in conversion of retinal to retinoic acid, could benefit from chemoprevention therapy. Expand
Role of Antigen-Processing Machinery in the In Vitro Resistance of Squamous Cell Carcinoma of the Head and Neck Cells to Recognition by CTL1
TLDR
The regulatory nature of the APM defects in SCCHN cells suggests that intralesional administration of IFN-γ may have a beneficial effect on the clinical course of the disease and on T cell-based immunotherapy of SCCHn by restoringSCCHN cell recognition by CTL. Expand
CSPG4 in cancer: multiple roles.
TLDR
Results indicate that CSPG4 is a promising new target to implement mAb-based immunotherapy of various types of cancer. Expand
A fresh look at augmenter of liver regeneration in rats
TLDR
ALR appears to be constitutively expressed in hepatocytes in an inactive form, and released from the cells in an active form by unknown means in response to partial hepatectomy and under other circumstances of liver maturation (as in weanling rats) or regeneration. Expand
Antitumor activity of human papillomavirus type 16 E7-specific T cells against virally infected squamous cell carcinoma of the head and neck.
TLDR
Immunohistochemistry of HPV-16+ SCCHN tumors showed that these antigen-processing machinery components are down-regulated in tumors in vivo compared with adjacent normal squamous epithelium, which supports further development of E7-specific immunotherapy and strategies for up-regulation of antigen- processing machinery components in HPV-associated SCCHn. Expand
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