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CP 115953

Known as: 3-Quinolinecarboxylic acid, 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-(4-hydroxyphenyl)-4-oxo-, CP-115,953 
National Institutes of Health

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Fluoroquinolones

Papers overview

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2001
2001
Cytotoxicity of Quinolones toward Eukaryotic Cells
The quinolone CP-115,953 (6,8-difluoro-7-(4-hydroxyphenyl) 1 cyclopropyl4 quinolone3 carboxylic acid) represents a novel… 
2000
2000
Increased sensitivity to quinolone antibacterials can be engineered in human topoisomerase IIalpha by selective mutagenesis.
A potential region of drug-DNA interaction in the A subunit of DNA gyrase has previously been identified from crystallographic… 
1998
1998
A Mutant Yeast Topoisomerase II (top2G437S) with Differential Sensitivity to Anticancer Drugs in the Presence and Absence of ATP*
To further characterize the mechanistic basis for cellular resistance/hypersensitivity to anticancer drugs, a yeast genetic… 
1997
1997
Quinolones share a common interaction domain on topoisomerase II with other DNA cleavage-enhancing antineoplastic drugs.
Topoisomerase II is the cytotoxic target for a number of clinically relevant antineoplastic drugs. Despite the fact that these… 
1995
1995
CP-115,953 stimulates cytokine production by lymphocytes
The cytotoxic quinolone CP-115,953 specifically exerts its inhibitory effect upon eukaryotic topoisomerase II. CP-115,953… 
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