Semantic Scholar uses AI to extract papers important to this topic.
Several important antineoplastic drugs kill cells by increasing levels of topoisomerase II-mediated DNA breaks. These compounds… Expand Topoisomerase II is the cytotoxic target for a number of clinically relevant antineoplastic drugs. Despite the fact that these… Expand A mutant yeast type II topoisomerase was generated by in vitro mutagenesis followed by selection in vivo for resistance to the… Expand Publisher Summary The type II enzyme of topoisomerases is required for proper chromosome structure and segregation, is involved… Expand Topoisomerase II is the target for two broad groups of clinically relevant drugs. Members of these groups are classically defined… Expand CP-115,953 [6,8-difluoro-7-(4'-hydroxyphenyl)-1-cyclopropyl-4- quinolone-3-carboxylic acid] is a novel quinolone that is highly… Expand To fully understand the mechanism of action of topoisomerase II-targeted agents, the effects of these drugs on the catalytic… Expand A previous study (M.J. Robinson, B.A. Martin, T.D. Gootz, P.R. McGuirk, M. Moynihan, J.A. Sutcliffe, and N. Osheroff, J. Biol… Expand The quinolone CP-115,953 (6,8-difluoro-7-(4-hydroxyphenyl)-1-cyclopropyl-4- quinolone-3-carboxylic acid) represents a novel… Expand The effects of two novel quinolone derivatives, CP-67,804 and CP-115,953 (the 1-ethyl and 1-cyclopropyl derivatives of 6,8… Expand