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CP 115953

Known as: 3-Quinolinecarboxylic acid, 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-(4-hydroxyphenyl)-4-oxo-, CP-115,953 
 
National Institutes of Health

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2003
2003
Several important antineoplastic drugs kill cells by increasing levels of topoisomerase II-mediated DNA breaks. These compounds… Expand
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1997
1997
Topoisomerase II is the cytotoxic target for a number of clinically relevant antineoplastic drugs. Despite the fact that these… Expand
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Highly Cited
1995
Highly Cited
1995
A mutant yeast type II topoisomerase was generated by in vitro mutagenesis followed by selection in vivo for resistance to the… Expand
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Review
1994
Review
1994
Publisher Summary The type II enzyme of topoisomerases is required for proper chromosome structure and segregation, is involved… Expand
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Highly Cited
1993
Highly Cited
1993
Topoisomerase II is the target for two broad groups of clinically relevant drugs. Members of these groups are classically defined… Expand
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1993
1993
To fully understand the mechanism of action of topoisomerase II-targeted agents, the effects of these drugs on the catalytic… Expand
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Highly Cited
1993
Highly Cited
1993
CP-115,953 [6,8-difluoro-7-(4'-hydroxyphenyl)-1-cyclopropyl-4- quinolone-3-carboxylic acid] is a novel quinolone that is highly… Expand
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Highly Cited
1992
Highly Cited
1992
A previous study (M.J. Robinson, B.A. Martin, T.D. Gootz, P.R. McGuirk, M. Moynihan, J.A. Sutcliffe, and N. Osheroff, J. Biol… Expand
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Highly Cited
1992
Highly Cited
1992
The quinolone CP-115,953 (6,8-difluoro-7-(4-hydroxyphenyl)-1-cyclopropyl-4- quinolone-3-carboxylic acid) represents a novel… Expand
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Highly Cited
1991
Highly Cited
1991
The effects of two novel quinolone derivatives, CP-67,804 and CP-115,953 (the 1-ethyl and 1-cyclopropyl derivatives of 6,8… Expand
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