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CP 115953

Known as: 3-Quinolinecarboxylic acid, 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-(4-hydroxyphenyl)-4-oxo-, CP-115,953 
National Institutes of Health

Papers overview

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2003
2003
Several important antineoplastic drugs kill cells by increasing levels of topoisomerase II-mediated DNA breaks. These compounds… 
1995
1995
In prokaryotic type II topoisomerases (DNA gyrases), mutations that result in resistance to quinolones frequently occur at Ser83… 
Highly Cited
1995
Highly Cited
1995
A mutant yeast type II topoisomerase was generated by in vitro mutagenesis followed by selection in vivo for resistance to the… 
Review
1994
Highly Cited
1993
Highly Cited
1993
Topoisomerase II is the target for two broad groups of clinically relevant drugs. Members of these groups are classically defined… 
Highly Cited
1993
Highly Cited
1993
CP-115,953 [6,8-difluoro-7-(4'-hydroxyphenyl)-1-cyclopropyl-4- quinolone-3-carboxylic acid] is a novel quinolone that is highly… 
1993
1993
To fully understand the mechanism of action of topoisomerase II-targeted agents, the effects of these drugs on the catalytic… 
Highly Cited
1992
Highly Cited
1992
A previous study (M.J. Robinson, B.A. Martin, T.D. Gootz, P.R. McGuirk, M. Moynihan, J.A. Sutcliffe, and N. Osheroff, J. Biol…