• Publications
  • Influence
Targeting DNA topoisomerase II in cancer chemotherapy
  • J. Nitiss
  • Biology, Medicine
  • Nature Reviews Cancer
  • 1 May 2009
Recent molecular studies have expanded the biological contexts in which topoisomerase II (TOP2) has crucial functions, including DNA replication, transcription and chromosome segregation. AlthoughExpand
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DNA topoisomerase II and its growing repertoire of biological functions
  • J. Nitiss
  • Medicine, Biology
  • Nature Reviews Cancer
  • 1 May 2009
DNA topoisomerases are enzymes that disentangle the topological problems that arise in double-stranded DNA. Many of these can be solved by the generation of either single or double strand breaks.Expand
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Roles of eukaryotic topoisomerases in transcription, replication and genomic stability
Topoisomerases introduce transient DNA breaks to relax supercoiled DNA, remove catenanes and enable chromosome segregation. Human cells encode six topoisomerases (TOP1, TOP1mt, TOP2α, TOP2β, TOP3αExpand
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Repair of topoisomerase I-mediated DNA damage.
Publisher Summary This chapter discusses the use of inhibitors of tyrosyl-DNA phosphodiesterase (Tdp1) and Chk1/2 in combination with Topoisomerase I (TopI) inhibitors. TopI is an abundant andExpand
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  • PDF
Tyrosyl-DNA phosphodiesterase (Tdp1) participates in the repair of Top2-mediated DNA damage.
Agents targeting topoisomerases are active against a wide range of human tumors. Stabilization of covalent complexes, converting topoisomerases into DNA-damaging agents, is an essential aspect ofExpand
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A Novel Mechanism of Cell Killing by Anti-topoisomerase II Bisdioxopiperazines*
Bisdioxopiperazines are a unique class of topoisomerase II inhibitors that lock topoisomerase II at a point in the enzyme reaction cycle where the enzyme forms a closed clamp around DNA. We examinedExpand
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Antitopoisomerase drug action and resistance.
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Proteolytic Degradation of Topoisomerase II (Top2) Enables the Processing of Top2·DNA and Top2·RNA Covalent Complexes by Tyrosyl-DNA-Phosphodiesterase 2 (TDP2)* ♦
Background: TDP2 is critical for repairing Top2 cleavage complexes (Top2cc) and as the VPg unlinkase for picornavirus replication. Results: Top2 proteolysis or denaturation is required for TDP2Expand
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Investigating the biological functions of DNA topoisomerases in eukaryotic cells.
  • J. Nitiss
  • Medicine, Biology
  • Biochimica et biophysica acta
  • 1 October 1998
DNA topoisomerases participate in nearly all events relating to DNA metabolism including replication, transcription, and chromosome segregation. Recent studies in eukaryotic cells have led to theExpand
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Aberrant Topoisomerase-1-DNA Lesions are Pathogenic in Neurodegenerative Genome Instability Syndromes
DNA damage is considered to be a prime factor in several spinocerebellar neurodegenerative diseases; however, the DNA lesions underpinning disease etiology are unknown. We observed the endogenousExpand
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