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COX14 gene

Known as: COX14, CHROMOSOME 12 OPEN READING FRAME 62, COX14 cytochrome c oxidase assembly factor 
 
National Institutes of Health

Papers overview

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2017
2017
A CMC1-knockout reveals translation-independent control of human mitochondrial complex IV biogenesis.
Defects in mitochondrial respiratory chain complex IV (CIV) frequently cause encephalocardiomyopathies. Human CIV assembly… Expand
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2017
2017
The Cox1 C-terminal domain is a central regulator of cytochrome c oxidase biogenesis in yeast mitochondria
Cytochrome c oxidase (CcO) is the last electron acceptor in the respiratory chain. The CcO core is formed by mitochondrial DNA… Expand
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2016
2016
A Novel Function of Pet54 in Regulation of Cox1 Synthesis in Saccharomyces cerevisiae Mitochondria*
Cytochrome c oxidase assembly requires the synthesis of the mitochondria-encoded core subunits, Cox1, Cox2, and Cox3. In yeast… Expand
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Highly Cited
2012
Highly Cited
2012
Mutations in C12orf62, a factor that couples COX I synthesis with cytochrome c oxidase assembly, cause fatal neonatal lactic acidosis.
We investigated a family in which the index subject presented with severe congenital lactic acidosis and dysmorphic features… Expand
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Highly Cited
2010
Highly Cited
2010
Coa3 and Cox14 are essential for negative feedback regulation of COX1 translation in mitochondria
Coa3 and Cox14 form assembly intermediates with newly synthesized Cox1 and are required for association of the Mss51… Expand
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Highly Cited
2010
Highly Cited
2010
Cox25 Teams Up with Mss51, Ssc1, and Cox14 to Regulate Mitochondrial Cytochrome c Oxidase Subunit 1 Expression and Assembly in Saccharomyces cerevisiae*
In the yeast Saccharomyces cerevisiae, mitochondrial cytochrome c oxidase (COX) biogenesis is translationally regulated. Mss51, a… Expand
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Highly Cited
2009
Highly Cited
2009
Dual functions of Mss51 couple synthesis of Cox1 to assembly of cytochrome c oxidase in Saccharomyces cerevisiae mitochondria.
Functional interactions of the translational activator Mss51 with both the mitochondrially encoded COX1 mRNA 5'-untranslated… Expand
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Highly Cited
2007
Highly Cited
2007
Shy1 couples Cox1 translational regulation to cytochrome c oxidase assembly.
Cytochrome c oxidase (complex IV) of the respiratory chain is assembled from nuclear and mitochondrially-encoded subunits… Expand
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Highly Cited
2004
Highly Cited
2004
Mss51p and Cox14p jointly regulate mitochondrial Cox1p expression in Saccharomyces cerevisiae.
Mutations in SURF1, the human homologue of yeast SHY1, are responsible for Leigh's syndrome, a neuropathy associated with… Expand
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1995
1995
Cloning and Characterization of COX14, Whose Product Is Required for Assembly of Yeast Cytochrome Oxidase (*)
Nuclear respiration-deficient mutants of Saccharomyces cerevisiae previously assigned to complementation group G93 lack… Expand
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