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CLEC4E gene

Known as: C-type lectin domain family 4 member E, MINCLE, C-TYPE LECTIN DOMAIN FAMILY 4, MEMBER E 
National Institutes of Health

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CLEC4A gene

Papers overview

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2016
2016
Binding Sites for Acylated Trehalose Analogs of Glycolipid Ligands on an Extended Carbohydrate Recognition Domain of the Macrophage Receptor Mincle*
The macrophage receptor mincle binds to trehalose dimycolate on the surface of Mycobacterium tuberculosis. Signaling initiated by… 
Highly Cited
2014
Highly Cited
2014
Fungal engagement of the C-type lectin mincle suppresses dectin-1-induced antifungal immunity.
Highly Cited
2013
Highly Cited
2013
Identification of distinct ligands for the C-type lectin receptors Mincle and Dectin-2 in the pathogenic fungus Malassezia.
Highly Cited
2013
Highly Cited
2013
Cord Factor and Peptidoglycan Recapitulate the Th17-Promoting Adjuvant Activity of Mycobacteria through Mincle/CARD9 Signaling and the Inflammasome
Although adjuvants are critical vaccine components, their modes of action are poorly understood. In this study, we investigated… 
Review
2012
Review
2012
C-type lectin receptor-induced NF-κB activation in innate immune and inflammatory responses
The C-type lectin receptors (CLRs) belong to a large family of proteins that contain a carbohydrate recognition domain (CRD) and… 
Highly Cited
2012
Highly Cited
2012
Neutrophils Promote Mycobacterial Trehalose Dimycolate-Induced Lung Inflammation via the Mincle Pathway
Trehalose 6,6′-dimycolate (TDM), a cord factor of Mycobacterium tuberculosis (Mtb), is an important regulator of immune responses… 
Highly Cited
2012
Highly Cited
2012
Role of Mincle in Alveolar Macrophage-Dependent Innate Immunity against Mycobacterial Infections in Mice
The role of macrophage-inducible C-type lectin Mincle in lung innate immunity against mycobacterial infection is incompletely… 
Review
2011
Review
2011
Survey of immune-related, mannose/fucose-binding C-type lectin receptors reveals widely divergent sugar-binding specificities.
C-type lectins (CTLs) are proteins that contain one or more carbohydrate-recognition domains (CRDs) that require calcium for… 
Review
2010
Review
2010
The role of Syk/CARD9 coupled C-type lectins in antifungal immunity
Fungal infections are affecting an increasing number of people, and the failure of current therapies in treating systemic… 
Highly Cited
2008
Highly Cited
2008
The Macrophage-Inducible C-Type Lectin, Mincle, Is an Essential Component of the Innate Immune Response to Candida albicans1
The recognition of carbohydrate moieties by cells of the innate immune system is emerging as an essential element in antifungal… 
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