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Nitric oxide protects against leukocyte-endothelium interactions in the early stages of hypercholesterolemia.
TLDR
Hypercholesterolemia induces microvascular dysfunction characterized by loss of endothelium-derived nitric oxide, increased rolling and adherence of leukocytes, and increased expression of P-selectin and ICAM-1. Expand
Direct measurement of nitric oxide release from vascular endothelial cells.
TLDR
The physiological usefulness of the amperometric measurement of NO employing a NO-specific electrode in biological systems is indicated and NO release was significantly attenuated by NG-nitro-L-arginine methyl ester and augmented by human superoxide dismutase. Expand
Cardioprotection by a novel recombinant serine protease inhibitor in myocardial ischemia and reperfusion injury.
TLDR
The recombinant serine protease inhibitor, LEX032, appears to be an effective agent for attenuating MI/R injury by inhibiting neutrophil-accumulation into the ischemic-reperfused myocardium and by inactivating cytotoxic metabolites (proteases and superoxide radical) released from neutrophils. Expand
Cardioprotective effects of selective inhibition of the two complement activation pathways in myocardial ischemia and reperfusion injury.
TLDR
Selective inhibition of the classical pathway of complement activation seems to be slightly more effective in limiting necrotic MI/R injury than the selective alternative pathway inhibition in this 24 h model of reperfusion injury, but equal doses of each inhibitor attenuated neutrophil accumulation. Expand
Protective actions of a leukotriene B4 antagonist in splanchnic ischemia and reperfusion in rats.
TLDR
Treatment with LY-255283 markedly ameliorated the deficits of endothelium-dependent relaxation of isolated superior mesenteric artery (SMA) rings in untreated SAO-shock rats and suggests that LTB4 plays a pivotal role in endothelial dysfunction occurring in SAO -shock rats by chemoattraction and activation of neutrophils on the surface of vascular endothelial cells. Expand
RGMA and IL21R show association with experimental inflammation and multiple sclerosis
TLDR
Rat chromosome 1 harbors overlapping quantitative trait loci for cytokine production and experimental models of inflammatory diseases and it is concluded that RGMA and IL21R and their pathways are crucial in MS pathogenesis and warrant further studies as potential biomarkers and therapeutic targets. Expand
Effects of trichlorfon and sodium dodecyl sulphate on antioxidant defense system and acetylcholinesterase of Tilapia nilotica in vitro
Foundation for Innovative Research Team of Jimei University [2007A001]; Nature Scientific Fund in Fujian Province, China [B0110034]
Mechanisms of vascular preservation by a novel NO donor following rat carotid artery intimal injury.
TLDR
This is the first study to demonstrate that NO plays a dual role in vascular cell proliferation, stimulating endothelial cells but inhibiting smooth muscle cell proliferation and an in vivo reduction in neointimal thickening and an acceleration of endothelial recovery determined by both anatomic and functional methods. Expand
Pulmonary artery endothelial dysfunction following ischemia and reperfusion of the rabbit lung.
TLDR
Pulmonary artery relaxation to the endothelium-dependent dilators ACh and A23187 appears to be mediated by the release of EDRF. Expand
Beneficial effect of SPM-5185, a cysteine-containing nitric oxide donor, in rat carotid artery intimal injury.
TLDR
The effects of an organic nitric oxide donor SPM-5185 in a rat carotid artery intimal injury model resulted in accelerated regeneration of endothelial cells on the intimal surface at 7 days, indicating a normal vascular smooth muscle response after intimal injuries. Expand
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