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CLCN2 gene

Known as: ClC-2, CLCN2, CHLORIDE CHANNEL 2 
National Institutes of Health

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Related topics

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CLCN1 gene

Papers overview

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Highly Cited
2007
Highly Cited
2007
Small‐conductance Cl– channels contribute to volume regulation and phagocytosis in microglia
The shape and volume of microglia (brain immune cells) change when they activate during brain inflammation and become migratory… 
Highly Cited
2004
Highly Cited
2004
Basolateral ClC-2 chloride channels in surface colon epithelium: regulation by a direct effect of intracellular chloride.
BACKGROUND & AIMS The principal function of the colon in fluid homeostasis is the absorption of NaCl and water. Apical membrane… 
Highly Cited
2003
Highly Cited
2003
A Conserved Pore‐Lining Glutamate as a Voltage‐ and Chloride‐Dependent Gate in the ClC‐2 Chloride Channel
ClC‐2 is a ubiquitously expressed, two‐pore homodimeric Cl− channel opened by hyperpolarisation. Little is known about its gating… 
Highly Cited
2002
Highly Cited
2002
ClC-2 in guinea pig colon: mRNA, immunolabeling, and functional evidence for surface epithelium localization.
The principal function of the colon in fluid homeostasis is the absorption of NaCl and water. Apical membrane Na(+) channels, Na… 
Highly Cited
2002
Highly Cited
2002
Phosphorylation and functional regulation of CIC‐2 chloride channels expressed in Xenopus oocytes by M cyclin‐dependent protein kinase
Many dramatic alterations in various cellular processes during the cell cycle are known to involve ion channels. In ascidian… 
Highly Cited
2001
Highly Cited
2001
ClC-2 Cl- channels in human lung epithelia: activation by arachidonic acid, amidation, and acid-activated omeprazole.
ClC-2 Cl- channels represent a potential target for therapy in cystic fibrosis. Key questions regarding the feasibility of using… 
Highly Cited
2000
Highly Cited
2000
Chloride channel activity of ClC-2 is modified by the actin cytoskeleton.
The chloride channel ClC-2 has been implicated in essential physiological functions, including cell-volume regulation and fluid… 
Highly Cited
2000
Highly Cited
2000
Swelling-induced taurine release without chloride channel activity in Xenopus laevis oocytes expressing anion channels and transporters.
Highly Cited
1998
Highly Cited
1998
Characterization of the hyperpolarization‐activated chloride current in dissociated rat sympathetic neurons
1 Dissociated rat superior cervical ganglion (SCG) neurons have been shown to possess a hyperpolarization‐activated inwardly… 
Highly Cited
1995
Highly Cited
1995
Cloning, functional expression, and characterization of a PKA-activated gastric Cl- channel.
cDNA encoding a Cl- channel was isolated from a rabbit gastric library, sequenced, and expressed in Xenopus oocytes. The… 
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